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A system that defines cellular organization and function is the microtubule (MT) cytoskeleton, a network of rod-like filaments that form and disassemble on the time scale of minutes. MTs assemble via head-to-tail association of αβ-tubulin. The polarity of tubulin gives the two ends of a MT distinct features, with α- and β-tubulins exposed respectively at the minus and plus ends. MT polymerization is controlled by GTP that is bound to tubulin and hydrolyzes to GDP upon incorporation of the tubulin into a MT. This polymerization-induced GTP hydrolysis underlies dynamic instability, wherein MTs switch randomly between states of polymerization and depolymerization.
Single MTs rarely function in isolation. Typically, MTs organize into higher order structures, such as bundles or radially symmetric arrays called asters. The mitotic spindle that forms during cell division is essentially two asters that connect via MT linkages with chromosomes. Bundles composed of tiled MTs, on the other hand, serve as tracks that enable long distance transport of cellular cargos in neurons. How do MT arrays organize? How are their dynamics regulated to control the physical and functional properties of these MT networks? These questions form the basis of my research program, which is to understand how MTs are organized and remodeled in space and time to carry out diverse biological functions.
Single MTs rarely function in isolation. Typically, MTs organize into higher order structures, such as bundles or radially symmetric arrays called asters. The mitotic spindle that forms during cell division is essentially two asters that connect via MT linkages with chromosomes. Bundles composed of tiled MTs, on the other hand, serve as tracks that enable long distance transport of cellular cargos in neurons. How do MT arrays organize? How are their dynamics regulated to control the physical and functional properties of these MT networks? These questions form the basis of my research program, which is to understand how MTs are organized and remodeled in space and time to carry out diverse biological functions.
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Brittany M Salazar,Ryoma Ohi
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Yun-Chen Chiang, In-Young Park,Esteban A. Terzo,Durga Nand Tripathi,Frank M. Mason,Catherine C. Fahey,Menuka Karki,Charles B. Shuster, Bo-Hwa Sohn,Pratim Chowdhury,Reid T. Powell,Ryoma Ohi,
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