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Human cells need a lot of energy to drive various physiological functions (e.g. heartbeat). This is mostly supplied by specialized cell structures called mitochondria, which extract energy from nutrients to make a more usable form of energy called ATP. These structures also make another molecule called reactive oxygen species (ROS), which can be dangerous in high enough quantities but are essential for cell health when kept at low amounts. ROS are kept in check by antioxidants, which are produced by the same pathways in mitochondria that make ATP. A complex interplay exists between ATP, ROS, and antioxidants which can have a significant impact on cell fate decisions. In addition, various environmental/physiological factors such as diet, exercise, gender, toxins and pollutants, and changes in temperature influence how much ATP, ROS, and antioxidants are made which can lead to changes in cell behavior. Dr. Mailloux’s work aims to decode how mitochondria can tailor the metabolic pathways that make ATP, ROS, and antioxidants in response to environmental and physiological cues. This includes delineating the effect of sex and gender as well as changes in diet affect these cell pathways.
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Nature reviews. Molecular cell biologypp.1-19, (2024)
Journal of Biological Chemistrypp.107159-107159, (2024)
The Journal of biological chemistryno. 12 (2023): 105399-105399
biorxiv(2023)
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Free Radical Biology and Medicine (2023): 287-300
JOURNAL OF BIOLOGICAL CHEMISTRYno. 12 (2023)
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