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Research interests
My research looks to use Drosophila melanogaster (fruit flies) as a powerful genetic model organism to dissect the molecular mechanisms contributing to neurodegenerative diseases including dementia, motor neurone disease and Parkinson’s disease. My primary research focuses on two overlapping neurodegenerative disorders, Frontotemporal Dementia (FTD) and Motor Neurone Disease (MND). I am particularly interested in how dipeptide-repeats associated with the disease causing hexanucleotide expansion within the C9orf72 gene contribute towards neurodegeneration. In the lab we have a number of Drosophila models of both FTD and MND including C9orf72 related DPRs, C9orf72 pure repeat models and models of CHMP2B, VCP and TDP-43 related disease. I am also interested in how we can use Drosophila as part of a translational pipeline both to understand the molecular mechanisms of disease and as part of a drug-screening strategy.
Research Interests
Papers共 65 篇Author StatisticsCo-AuthorSimilar Experts
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Acta neuropathologica communicationsno. 1 (2023): 1-18
Journal of Biological Chemistryno. 3 (2022): 101712-101712
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY (2022)
Comprehensive Heterocyclic Chemistry IVpp.383-394, (2022)
semanticscholar(2021)
Ron Carico,Ryan West, Tiffany Miller, Jessica Brown, Dustin Baum, Sarah Dunaway, Alexander Hill, Will Finley, Jesse Bates,Jeff Fenerty
Neurobiology of Disease (2021)
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#Papers: 61
#Citation: 917
H-Index: 18
G-Index: 27
Sociability: 5
Diversity: 0
Activity: 1
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