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Bio
Research Interests
Ruth's primary research interests focus on the identification of genes and genetic loci contributing to the risk of obesity and related metabolic traits. She has been involved in gene - discovery since 2005, when ‘genome - wide association’ was introduced and has since actively contributed to many consortia that use this approach to identify genetic loci for a large number of metabolic traits. Increasingly, her gene - discovery work also focuses on the identification of low - frequency variants through the implementation exome - chip genotyping and sequencing projects, not only in individuals of white European descent, but also in those of African and Hispanic decent.
She is a member of steering committee of the GIANT (Genetic Investigation of ANTropometric Traits) consortium, led by Professor Joel Hirschhorn and is actively involved in the many working groups. She has set up the Genome - Wide Association Study (GWAS) consortia for body fat percentage, for leptin levels, and also for resting heart rate. Furthermore, she has been involved in the GWAS consortia for blood pressure (ICBP), lipids (GLGC), glucose and insulin (MAGIC), and type 2 diabetes (DIAGRAM), amongst others.
Besides gene-discovery, she uses epidemiological methods to follow - up on established loci with the aim to elucidate the pathways through which they increase risk of metabolic disease. Furthermore, her work also assesses the public health implications of the established loci by examining their predictive value and their interaction with lifestyle factors such as diet and physical activity.
Research Interests:
Gene-discovery for obesity and related metabolic traits
Role of low-frequency variants in metabolic traits
Genetic contribution to obesity and related metabolic traits in individuals of African and Hispanic origin
Gene-environment interaction to study the influence of lifestyle on the genetic susceptibility to obesity and related metabolic traits
The value of genetic prediction for obesity and related metabolic disease
Use of epidemiological methods to gain insights in the pathways that connect genetic loci to increased risk of disease
Research Interests
Papers共 832 篇Author StatisticsCo-AuthorSimilar Experts
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The American Journal of Human Geneticsno. 6 (2024): 1035-1046
Marios K Georgakis,Rainer Malik,Omar El Bounkari,Natalie R Hasbani,Jiang Li,Jennifer E Huffman,Gabrielle Shakt, Reinier W P Tack, Tamara N Kimball,Yaw Asare,Alanna C Morrison,Noah L Tsao,
Yana Hrytsenko, Benjamin Shea,Michael Elgart,Nuzulul Kurniansyah,Genevieve Lyons,Alanna C. Morrison,April P. Carson,Bernhard Haring,Braxton D. Mitchell,Bruce M. Psaty,Byron C. Jaeger,C. Charles Gu,
Hanfei Xu, Shreyash Gupta, Ian Dinsmore, Abbey Kollu, Anne Marie Cawley, Mohammad Y Anwar,Hung-Hsin Chen,Lauren E Petty,Sudha Seshadri,Misa Graff, Piper Below,Jennifer A Brody,
medRxiv : the preprint server for health sciences (2024)
crossref(2024)
Soo Heon Kwak, Ryan B Hernandez-Cancela,Daniel A DiCorpo,David E Condon,Jordi Merino,Peitao Wu,Jennifer A Brody,Jie Yao,Xiuqing Guo,Fariba Ahmadizar,Mariah Meyer,Murat Sincan,
NATURE COMMUNICATIONSno. 1 (2024): 3800-3800
Circulation. Genomic and precision medicineno. 3 (2024): e004320-e004320
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Author Statistics
#Papers: 834
#Citation: 103033
H-Index: 141
G-Index: 314
Sociability: 10
Diversity: 0
Activity: 10
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