Randal R Ketchem - Department of Protein Sciences;Amgen Inc;Department of Protein Sciences, Amgen Inc

基本信息

Career Trajectory

Bio

My research direction is focused on computational structural biology while also applying my skills to broader platform review and direction. Working in areas of antibody design, epitope mapping, molecular assessment, stability engineering, construct design, protein engineering and serving on therapeutic area teams to lead target development.

Research Interests

Papers共 83 篇Author StatisticsCo-AuthorSimilar Experts

By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选

A Comprehensive Engineering Strategy Improves Potency and Manufacturability of a Near Pan-neutralizing Antibody Against HIV

Mohammad M Sajadi,Abdolrahim Abbasi,Zahra Rikhtegaran Tehrani,Christine Siska,Rutilio Clark, Woo Chi,Michael S Seaman,Dieter Mielke,Kshitij Wagh,Qingbo Liu, Taylor Jumpa,Randal R Ketchem,Dung N Nguyen, William D Tolbert,Brian G Pierce,Ben Atkinson, Derrick Deming,Megan Sprague, Andrew Asakawa, David Ferrer, Yasmin Dunn, Sarah Calvillo,Rui Yin,Johnathan D Guest,Bette Korber,Bryan T Mayer,Alicia H Sato,Xin Ouyang, Scott Foulke, Parham Habibzadeh,Maryam Karimi, Arash Aslanabadi, Mahsa Hojabri,Saman Saadat, Roza Zareidoodeji, Mateusz Kędzior,Edwin Pozharski,Alonso Heredia, Hegang Chen,David Montefiori,Guido Ferrari,Marzena Pazgier,George K Lewis,Joseph G Jardine,Paolo Lusso,Anthony DeVico

Structure (London, England 1993) (2025)

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AI-based Antibody Discovery Platform Identifies Novel, Diverse and Pharmacologically Active Therapeutic Antibodies Against Multiple SARS-CoV-2 Strains

Cristina Moldovan Loomis,Thomas Lahlali,Danielle Van Citters,Megan Sprague,Gregory Neveu, Laurence Somody,Christine C. Siska, Derrick Deming, Andrew J. Asakawa,Tileli Amimeur,Jeremy M. Shaver, Caroline Carbonelle,Randal R. Ketchem,Antoine Alam,Rutilio H. Clark

ANTIBODY THERAPEUTICSno. 4 (2024): 307-323

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Somatic Hypermutation-Mediated Paratope Flexibility Improves the Cross-Reactivity of Human Malaria Antibodies

Rajagopal Murugan,Anton Hanke,Opeyemi Ernest Oludada,Giulia Costa,Yevel Flores-Garcia,Ghulam Mustafa,Kan Li,Richard H. C. Huntwork,Gillian Q. Horn,S. Moses Dennison,Georgia D Tomaras,Fidel Zavala,Elena A. Levashina,Randal R. Ketchem,Rebecca C. Wade,Hedda Wardemann

biorxiv（2024）

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An Antibody Drug Engineered for Prevention of Malaria in Global Populations

openalex（2023）

Cited1Views0Bibtex

AI-based Antibody Discovery Platform Identifies Novel, Diverse and Pharmacologically Active Therapeutic Antibodies Against Multiple SARS-CoV-2 Strains

openalex（2023）

Cited1Views0Bibtex

Designing Feature-Controlled Humanoid Antibody Discovery Libraries Using Generative Adversarial Networks

Tileli Amimeur,Jeremy M. Shaver,Randal R. Ketchem, J. Alex Taylor,Rutilio H. Clark, Josh Smith,Danielle Van Citters,Christine C. Siska,Pauline Smidt,Megan Sprague,Bruce A. Kerwin,Dean Pettit

bioRxiv (2020)

Cited57Views0Bibtex

Chapter 9: Leveraging the Multi-attribute Method (MAM) to Improve Biotherapeutic Development

Lisa Connell-Crowley,Bruce Kerwin,Randal Ketchem, Jeff McGrew,Richard S. Rogers

Development of Biopharmaceutical Drug-Device ProductsAAPS Advances in the Pharmaceutical Sciences Seriespp.215-231, (2020)

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Framework Mutations of the 10-1074 Bnab Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity

Bruce A. Kerwin,Chelsey Bennett,Yan Brodsky,Rutilio Clark,J. Alaina Floyd,Alison Gillespie,Bryan T. Mayer,Megan McClure,Christine Siska,Michael S. Seaman,Kelly E. Seaton,Jeremy Shaver,Georgia D. Tomaras,Nicole L. Yates,Randal R. Ketchem

Journal of Pharmaceutical Sciences（2019）

Cited14Views0WOSBibtex

Optimizing A Monoclonal Antibody For Manufacturability, Stability, And Cost

Julee Floyd,Christine Siska,Alison Gillespie,Megan Mcclure,Yan Brodsky,Jeremy Shaver,Rutilio Clark,Randal Ketchem,Bruce Kerwin

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (2018)

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