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职业迁徙
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My interest is in the brain mechanisms of motivation and addiction. Our current studies focus on the mesolimbic and nigrostriatal dopamine systems, systems that appear to stamp in or “reinforce” stimulus-stimulus, stimulus-response, and response-outcome learning involved in habit formation. These systems are activated by addictive drugs, unexpected rewards, and reward predictors, and they are modified by experience with drugs of abuse. We are interested in the neuronal inputs that carry reward-predictive signals and we are interested in drug-induced modifications that, for example, change the sensitivity of the system to stress. Our current studies are based on microdialysis studies of intravenous drug self-administration and involve interdisciplinary collaborations involving histochemistry, electrophysiology, in vivo voltammetry, and cell biology. Of particular interest are manipulations of the glutamatergic, cholinergic, and CRF inputs to the ventral tegmental area using receptor-specific neurotoxins, small interfering RNA, and viral overexpression of the glutamate-1 transporter.
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Annual review of psychology (2020): 79-106
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2019)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2019)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2019)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2019)
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2019)
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