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Research Interests
Next-Generation RNA Therapeutics: We develop efficient synthetic methods to make novel RNA mimetics with improved stability, translation efficiency, and reduced immunogenicity for therapeutic applications including miRNA, siRNA, protein-replacement therapy, mRNA vaccine, and CRISPR.
Reprogram RNA with Small-Molecule: We develop general cell-based platforms to identify selective RNA-binding small molecules and use optimized molecules to inhibit/activate RNA function (e.g., translation), degrade RNA, induce alternative splicing, and even edit RNA in vivo.
Enzyme-Like DNA Catalyst Design: We design enzyme-like DNA catalyst by merging small-molecule catalysts (i.e., co-factor) with programmable DNA structures (i.e., chiral environment) for unsolved reactivity and selectivity problems in a more sustainable way.
Next-Generation RNA Therapeutics: We develop efficient synthetic methods to make novel RNA mimetics with improved stability, translation efficiency, and reduced immunogenicity for therapeutic applications including miRNA, siRNA, protein-replacement therapy, mRNA vaccine, and CRISPR.
Reprogram RNA with Small-Molecule: We develop general cell-based platforms to identify selective RNA-binding small molecules and use optimized molecules to inhibit/activate RNA function (e.g., translation), degrade RNA, induce alternative splicing, and even edit RNA in vivo.
Enzyme-Like DNA Catalyst Design: We design enzyme-like DNA catalyst by merging small-molecule catalysts (i.e., co-factor) with programmable DNA structures (i.e., chiral environment) for unsolved reactivity and selectivity problems in a more sustainable way.
Research Interests
Papers共 57 篇Author StatisticsCo-AuthorSimilar Experts
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合作机构
Kenneth Lye,Rowan D. Young
CHEMICAL SCIENCEno. 8 (2024): 2712-2724
Journal of organometallic chemistry (2023): 122617-122617
Advanced science (Weinheim, Baden-Wurttemberg, Germany)no. 36 (2023): e2305768-e2305768
Journal of organic chemistryno. 7 (2023): 4397-4404
Tetrahedron Chem (2023): 100050-100050
SYNTHESIS-STUTTGARTno. 07 (2022): 1671-1683
Angewandte Chemieno. 49 (2022): e202210917-e202210917
Chemical Communications 58 (93), 12947-12950 (2022)
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Chemical communications (Cambridge, England)no. 93 (2022): 12947-12950
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Author Statistics
#Papers: 55
#Citation: 1101
H-Index: 20
G-Index: 32
Sociability: 4
Diversity: 2
Activity: 30
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