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Next-Generation RNA Therapeutics: We develop efficient synthetic methods to make novel RNA mimetics with improved stability, translation efficiency, and reduced immunogenicity for therapeutic applications including miRNA, siRNA, protein-replacement therapy, mRNA vaccine, and CRISPR.
Reprogram RNA with Small-Molecule: We develop general cell-based platforms to identify selective RNA-binding small molecules and use optimized molecules to inhibit/activate RNA function (e.g., translation), degrade RNA, induce alternative splicing, and even edit RNA in vivo.
Enzyme-Like DNA Catalyst Design: We design enzyme-like DNA catalyst by merging small-molecule catalysts (i.e., co-factor) with programmable DNA structures (i.e., chiral environment) for unsolved reactivity and selectivity problems in a more sustainable way.
Next-Generation RNA Therapeutics: We develop efficient synthetic methods to make novel RNA mimetics with improved stability, translation efficiency, and reduced immunogenicity for therapeutic applications including miRNA, siRNA, protein-replacement therapy, mRNA vaccine, and CRISPR.
Reprogram RNA with Small-Molecule: We develop general cell-based platforms to identify selective RNA-binding small molecules and use optimized molecules to inhibit/activate RNA function (e.g., translation), degrade RNA, induce alternative splicing, and even edit RNA in vivo.
Enzyme-Like DNA Catalyst Design: We design enzyme-like DNA catalyst by merging small-molecule catalysts (i.e., co-factor) with programmable DNA structures (i.e., chiral environment) for unsolved reactivity and selectivity problems in a more sustainable way.
研究兴趣
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Journal of Organometallic Chemistry (2023): 122617-122617
Advanced science (Weinheim, Baden-Wurttemberg, Germany)no. 36 (2023): e2305768-e2305768
The Journal of organic chemistryno. 7 (2023): 4397-4404
Tetrahedron Chem (2023): 100050-100050
Angewandte Chemieno. 49 (2022): e202210917-e202210917
Chemical Communications 58 (93), 12947-12950 (2022)
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Chemical communications (Cambridge, England)no. 93 (2022): 12947-12950
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