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My main scientific interest is to contribute to an understanding of the complex interactions between human intestinal mucosa and the environment in health and disease. I started in the field by investigating functional effects of positional genetic signals in inflammatory bowel disease. A particular focus is on cellular pathways and networks of NOD-like receptors, autophagy and ER stress. We understand that in intestinal inflammation the human host, together with its associated gut microbiome must be regarded as a functional unit. Disease mechanisms can, therefore, only be described when taking both sides of this “metaorganism” into account. For our questions, we also develop novel tools and techniques using large-scale sequencing and bioinformatics to understand regulatory events and cellular/bacterial response profiles in model systems of chronic inflammatory diseases. I am a member of several large-scale sequencing consortia delineating the genomic and epigenomic architecture of human (inflammatory) diseases.
Research Interests
Papers共 663 篇Author StatisticsCo-AuthorSimilar Experts
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Lina Welz, Na-mi Kim,Danielle M. Harris, Abrar Alsaadi, Mhmd Oumari, Graziella Credidio,Jan Taubenheim,Valery Volk,Florian Tran, Laura K. Sievers,Eric Koncina,Bram Verstockt,
Gastroenterologyno. 5 (2024): S-1405
Danielle M. M. Harris,Silke Szymczak,Sven Schuchardt, Johannes Labrenz,Florian Tran,Lina Welz,Hanna Grasshoff, Henner Zirpel, Melike Suembuel, Mhmd Oumari, Nils Engelbogen,Ralf Junker,
EBIOMEDICINE (2024): 105056-105056
Genome biologyno. 1 (2024): 81-81
United European gastroenterology journalno. 6 (2024): 737-748
Florian Tran, Alena Scharmacher,Nathan Baran,Neha Mishra, Marek Wozny, Samuel Pineda Chavez,Archana Bhardwaj,Sophia Hinz,Simonas Juzenas,Joana P Bernardes,Laura Katharina Sievers,Matthias Lessing,
Scientific reportsno. 1 (2024): 10925-10925
Lisa-Marie Rieckmann,Michael Spohn, Lisa Ruff,David Agorku,Lisa Becker,Alina Borchers,Jenny Krause, Roisin O’Reilly, Jurek Hille,Janna-Lisa Velthaus-Rusik, Niklas Beumer, Armin Günther,
Molecular Cancerno. 1 (2024): 1-9
Sophia Rüsing,Lina Welz,Constanze Pfitzer, Danielle Monica Harris,Christoph Röcken,Philip Rosenstiel,Susanna Nikolaus,Florian Tran,Stefan Schreiber,Konrad Aden,Laura Katharina Sievers
Clinical and translational gastroenterology (2024)
Åsa Johansson, Mahadevan Venkita Subramani,Bahtiyar Yilmaz,Elisabeth Nyström, Elena Layunta,Liisa Arike,Felix Sommer,Philip Rosenstiel,Lars Vereecke, Louise Mannerås Holm, Andy Wullaert,Thaher Pelaseyed,
bioRxiv : the preprint server for biology (2024)
biorxiv(2024)
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