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Our overarching question is: how do mutations in genes involved in the activation and regulation of T cell responses contribute to regulation of immune homeostasis and at what point do perturbations in homeostatic mechanisms tip over into autoimmunity? Activation and termination of immune responses are balanced through cross-talk between tyrosine kinases and phosphatases immediately downstream of the T cell receptor (TCR). Changes in expression and point mutations in these influential kinases and phosphatases have been linked to autoimmunity; how do these mutations perturb homeostasis and result in a failure of regulation? At what point do perturbations in the homeostatic balance of the immune system tip into immunopathology and autoimmunity? What are the mechanisms that underlie these processes? Finally we are using the knowledge gained from autoimmune T cells to try and adapt anti-cancer T cell responses for immunotherapy.
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Methods in molecular biology (Clifton, N.J.) (2024): 81-92
RNA (New York, N.Y.)no. 1 (2024): 26-36
Atsushi Tanaka,Shinji Maeda,Takashi Nomura,Mara Anais Llamas-Covarrubias, Satoshi Tanaka,Lin Jin,Ee Lyn Lim,Hiromasa Morikawa,Yohko Kitagawa,Shuji Akizuki,Yoshinaga Ito, Chihiro Fujimori,
Journal for ImmunoTherapy of Cancerno. 12 (2023)
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