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个人简介
My major research interest is the analysis (isolation, separation, identification and quantification) of drugs, including drugs of abuse, drug metabolites, endogenous amines and amino acids, and environmental chemicals in biological (urine, blood, CSF, brain, etc) and in environmental samples, in herbal products and in foodstuffs. The analytical methods that I have developed are effective even when only trace quantities of analytes are present. An emphasis is placed on derivatization of organic compounds in aqueous biological tissues and solutions, prior to their extraction and analysis, especially by combined gas chromatography/mass spectrometry. An ability to interpret organic mass spectra is required for these studies.
I am also interested in the metabolism and pharmacokinetics in neonates, adults, elderly patients and animal models of various neurochemicals, especially antidepressant drugs (phenelzine, tranylcypromine, trimipramine, imipramine, amitriptyline, fluoxetine, other SSRIs, haloperidol, etc); endogenous amines (e.g. phenylethylamine, tryptamine, histamine), and their prodrugs; amino acids; methylphenidate; diethylpropion; and fenfluramine.
I also conduct in vitro drug metabolism studies using isolated pure human cytochrome P450 isozymes and investigate the effects of inducers and inhibitors on drug metabolism. Drug/drug interactions are also of interest in view of the fact that many patients simultaneously receive more than one drug.
研究兴趣
论文共 120 篇作者统计合作学者相似作者
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Chemistry of Heterocyclic Compounds A Series Of MonographsChemistry of Heterocyclic Compounds (2008)
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#Papers: 120
#Citation: 1993
H-Index: 25
G-Index: 37
Sociability: 5
Diversity: 3
Activity: 0
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