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The underlying theme of my research has been to explore structure – function relationships in the brain. To this end, my work has focused on uncovering the morphological changes in the brain that are responsible for the cognitive decline seen in aging and disease processes. In initial studies, I used developmental techniques to examine specific structure-function relationships in the memory system of non-human primates. I continued on to conduct studies of normal aging and cerebrovascular disease. In this work I have focused on characterize the cognitive changes taking place in non-human primate models. As my interests in studying the brain grew, I become involved in structural Magnetic Resonance Imaging (MRI) studies of normal aging and disorders such as Alzheimer’s disease. In this work I have been quantifying volumetric changes taking place in the brain in the course of the disease processes. This work continues to evolve and has changed focus somewhat in the recent years to include studies aimed at exploring the value of MRI in predicting which subjects will progress to develop cognitive decline and Alzheimer’s disease and which will remain cognitively stable.
研究兴趣
论文共 231 篇作者统计合作学者相似作者
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FRONTIERS IN NEUROSCIENCE (2024): 1301066-1301066
MEDICAL IMAGE ANALYSIS (2024): 103043-103043
Neurobiology of aging (2023): 33-42
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORINGno. 4 (2023)
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biorxiv(2023)
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORINGno. 4 (2023): n/a-n/a
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurologyno. 3 (2023): 166-177
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Journal of the International Neuropsychological Societyno. s1 (2023): 409-410
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NEUROLOGYno. 17 (2023)
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