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个人简介
Ronald Breslow was born in Rahway, New Jersey on March 14, 1931. Breslow was born in Rahway, New Jersey, the son of Gladys (Fellows) and Alexander E. Breslow. He was interested in the design and synthesis of new molecules with interesting properties, and the study of these properties. Examples include the cyclopropenyl cation, the simplest aromatic system and the first aromatic compound prepared with other than six electrons in a ring. His seminal contributions include the correct site of reactivity of thiamin diphosphate in enzymes that promote the decarboxylation of pyruvate – based on his pioneering use of proton NMR with small molecule analogues – and the rate enhancement provided by binding to cyclodextrins produced major themes for study in modern organic and biological chemistry. He also co-discovered the histone deacetylase inhibitor SAHA (Vorinostat) which is FDA-approved for the treatment of cutaneous T-cell lymphoma.
研究兴趣
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Routledge eBookspp.27-40, (2023)
mag(2015)
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