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First, the lab is investigating the significance of growth factor signaling mechanisms in the regulation of islet biology by creating genetic models to examine the roles of insulin/IGF-1 receptors and their substrate proteins. The lab has used conditional knockouts to complement in vitro models using primary islets from humans/rodents to dissect cross-talk between insulin/IGF-I, glucose, and incretin (glucagon like-peptide-1) signaling pathways in islet cells. We are using transplantation/parabiotic approaches to investigate inter-organ communication (e.g. between islets and liver/brain/adipose) to identify islet cell growth factors. Finally, we are studying pathways utilized by lymphocytes that allow regeneration of beta cells in type 1 diabetes.
Research Interests
Papers共 388 篇Author StatisticsCo-AuthorSimilar Experts
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Nature Cell Biologyno. 3 (2024): 421-437
The Journal of clinical investigation (2024)
NATURE CELL BIOLOGY (2024)
Diabetesno. Supplement_1 (2023)
Hyunki Kim,Yan Li,Hongming Zhu, Zhenshuo Ren,Khadija El Jellas, Namrata Shukla,Mengjie Chen,ROHIT KULKARNI
Diabetesno. Supplement_1 (2023)
DIABETESno. Supplement_1 (2023)
Giorgio Basile,Amedeo Vetere,Jiang Hu,Oluwaseun Ijaduola,Yi Zhang,Ka-Cheuk Liu,Amira M Eltony,Dario F De Jesus, Kazuki Fukuda, Grace Doherty,Colin A Leech,Oleg G Chepurny,
Cell metabolismno. 7 (2023): 1242-1260.e9
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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