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Stromal cells in the bone marrow, spleen and lymph nodes provide anchors, survival factors and extracellular matrices that guide immune cells during homeostasis, or upon activation, to their final destination and effector function. I have shown that interference with the communication of immune cells and their microenvironment, both in health and disease (i.e. lymphoid cancers and rheumatoid arthritis), is detrimental for their development, survival, and function. One of the major topics in relation to this essential interaction is the role of proteoglycans. Proteoglycans are major players in formation of extracellular matrices, but can also be functional as co-receptors at the cell surface enhancing cell signaling. Knocking-out certain modifications of proteoglycans, either in immune cells, the stromal compartment or both, revealed that proteoglycans have a crucial contribution in the normal development and function of lymphoid organs and the development, antigen-dependent differentiation, and survival of lymphocytes, in health and disease.
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Journal for immunotherapy of cancerno. 6 (2023): e006699-e006699
EUROPEAN JOURNAL OF IMMUNOLOGY (2022): 360-360
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P. Djali,K. Das, Y. Bar-Ephraim,A. Candelli, E. Fong, Y. Patankar,R. Reijmers,I. Sarkar, W. Singleterry, Z. Yu,J. Ashby
EUROPEAN JOURNAL OF IMMUNOLOGY (2022): 368-368
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J. Ashby, Y. Bar-Ephraim,A. Candelli,K. Das, P. Djali, E. Fong, Y. Patankar,R. Reijmers,I. Sarkar, W. Singleterry, Z. Yu
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