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个人简介
Eukaryotic cells have evolved a number of mechanisms to respond to environmental stress. These stress responses are tempered by growth factors and other signals from surrounding cells in multicellular organisms. Our research programme involves the mechanisms whereby these cellular signals are regulate mammalian cells. Phosphoinositide 3-kinases (PI3Ks) modify lipid membranes and the modified phospholipids produced by the enzymes serve as second messengers and sorting signals, and they are important for cell response to environmental cues. PI3Ks are part of a larger family of kinases that also include the PI3K-related protein kinases (PIKKs). We study the structures, dynamics and functions of PIKKs and related pathways in cellular signalling, sorting and nutrition.
研究兴趣
论文共 271 篇作者统计合作学者相似作者
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Clarissa N. Pacyna,Madhanagopal Anandapadamanaban,Kevin W. Loudon, Iain M. Hay,Olga Perisic,Ruoyan Li, Matthew Byrne, Laura Allen,Kirsty Roberts,Yvette Hooks,Anne Y. Warren,Grant D. Stewart,
biorxiv(2023)
CELL REPORTSno. 3 (2023): 112172-112172
bioRxiv the preprint server for biology (2023)
Science advancesno. 39 (2023)
NATUREno. 7963 (2023): 159-168
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作者统计
#Papers: 272
#Citation: 25691
H-Index: 82
G-Index: 158
Sociability: 7
Diversity: 4
Activity: 27
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