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Brain tumors are diagnosed in more than 20,000 Americans annually. The most malignant neoplasm, glioblastoma, is also the most common. Similarly, brain tumors constitute the most common solid neoplasm in children and include astrocytomas of the cerebellum, brain stem and cerebrum as well as medulloblastomas of the cerebellum. My colleagues and I have endeavored to translate the bench discoveries of genetic mutations and aberrant protein expressions found in brain tumors to better understand the processes involved in the etiology, pathogenesis, and treatment of brain tumors. Using the resources of the Preston Robert Brain Tumor Biorepository at Duke, our team, consisting of Henry Friedman, Allan Friedman, and Hai Yan and lead by Darell Bigner, have helped to identify mutations in Isocitrate Dehydrogenase (IDH1 and IDH2) as a marker of good prognosis in gliomas of adults. This test is now offered at Duke as a clinical test. Working with the Molecular Pathology Laboratory at Duke, we have also brought testing for TERT promoter region mutations as another major test for classifying gliomas in adults. Our collaboration with the Toronto Sick Kids Hospital has resulted in prognostic testing for childhood medulloblastomas, primitive neuroectodermal tumors, and ependymomas at Duke.
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Papers共 390 篇Author StatisticsCo-AuthorSimilar Experts
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Dmytro Klymyshyn,Vaibhav Jain, Lauren Whaley,Emily Hocke,Bassem Ben Cheikh, Alan Smith,Karen Abramson,Nadine Nelson, Diane Satterfield, Elizabeth Thomas,Giselle Lopez, Seetha Hariharan,
Cancer Researchno. 6_Supplement (2024): 5496-5496
Kirit Singh,Matthew W Foster, Marlene J Violette,Kelly M Hotchkiss, Chelsea O Railton, Emily E Blandford, Kathryn E Blethen, Elizabeth L Thomas,David M Ashley,Annick Desjardins,Henry S Friedman,Margaret O Johnson,
medrxiv(2024)
crossref(2023)
crossref(2023)
The Lancet. Child & adolescent healthno. 7 (2023): 471-478
Simon Gregory,Vaibhav Jain,Emily Hocke,Karen Abramson, Elizabeth Thomas, Diane Satterfield,Kyle Walsh,Michael C. Brown,Roger E. McLendon,David Ashley
Neuro-oncologyno. Supplement_5 (2023): v290-v291
crossref(2023)
crossref(2023)
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