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Phototransduction, TRP channels and Calcium signalling in Drosophila
Phototransduction in the fruitfly Drosophila is an important model for G-protein coupled signalling and fascinating in its own right. We study the underlying cellular and molecular machinery using a combination of molecular genetic, physiological and computational approaches. A major interest concerns the mechanisms of activation and regulation of the light-sensitive channels. These are encoded by the trp gene, which is the defining member of the intensively studied TRP ion channel family, with ~30 mammalian isoforms widely implicated in sensory transduction and Ca2+ signalling throughout the body.
Other areas of interest include
(i) molecular mechanisms of retinal degeneration
(ii) a novel class of ligand gated chloride channel directly gated by the photoreceptor neurotransmitter histamine
(iii) voltage gated potassium channels
(iv) Sodium calcium exchange
Phototransduction, TRP channels and Calcium signalling in Drosophila
Phototransduction in the fruitfly Drosophila is an important model for G-protein coupled signalling and fascinating in its own right. We study the underlying cellular and molecular machinery using a combination of molecular genetic, physiological and computational approaches. A major interest concerns the mechanisms of activation and regulation of the light-sensitive channels. These are encoded by the trp gene, which is the defining member of the intensively studied TRP ion channel family, with ~30 mammalian isoforms widely implicated in sensory transduction and Ca2+ signalling throughout the body.
Other areas of interest include
(i) molecular mechanisms of retinal degeneration
(ii) a novel class of ligand gated chloride channel directly gated by the photoreceptor neurotransmitter histamine
(iii) voltage gated potassium channels
(iv) Sodium calcium exchange
Research Interests
Papers共 292 篇Author StatisticsCo-AuthorSimilar Experts
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JOURNAL OF CELL SCIENCEno. 18 (2023)
Joni Kemppainen,Ben Scales,Keivan Razban Haghighi,Jouni Takalo,Neveen Mansour, James McManus,Gabor Leko, Paulus Saari,James Hurcomb,Andra Antohi,Jussi-Petteri Suuronen,Florence Blanchard,
Proceedings of the National Academy of Sciencesno. 12 (2022)
Proceedings of the National Academy of Sciences of the United States of Americano. 12 (2022)
bioRxiv (Cold Spring Harbor Laboratory) (2021)
bioRxiv (Cold Spring Harbor Laboratory)pp.1-38, (2020)
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