基本信息
views: 100
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Quantitative Electrophysiology - Activation of the Heart. Simulation studies are being conducted on the activation process in cardiac tissue. To carry this out it is necessary to describe quantitatively the electrical (nonlinear) behavior of the cell membrane as well as to describe the electrical ``load" (i.e. the electrical structure and conductivities of the intracellular and extracellular medium). For studies which emphasize activation alone the Hodgkin-Huxley and Ebihara-Johnson membrane models have been used. Where recovery is important the Beeler-Reuter and DiFrancesco-Noble models have been introduced.
Regarding the passive conductive properties of the cardiac muscle, because of its syncytial nature (arising from multiple low resistance intercellular junctions) the intracellular and interstitial space can be regarded as continua though coupled at all points through the cell membrane. This constitutes what has been called the bidomain model and is the basis for a partial differential equation description of the fields of interest. The directional differences in conductivity arising from the fiber orientation and myofibril structure can be taken into account by using an anisotropic conductivity tensor. In general the ratio of conductivities in the intracellular and interstitial spaces are unequal, according to the isolated experiments in the literature.
Regarding the passive conductive properties of the cardiac muscle, because of its syncytial nature (arising from multiple low resistance intercellular junctions) the intracellular and interstitial space can be regarded as continua though coupled at all points through the cell membrane. This constitutes what has been called the bidomain model and is the basis for a partial differential equation description of the fields of interest. The directional differences in conductivity arising from the fiber orientation and myofibril structure can be taken into account by using an anisotropic conductivity tensor. In general the ratio of conductivities in the intracellular and interstitial spaces are unequal, according to the isolated experiments in the literature.
Research Interests
Papers共 89 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
American journal of physiology. Heart and circulatory physiologyno. 12 (2014): H1660-8
R Turco, Lenore Tedesco,Linda Stalker Prokopy,John S Wilson,Jane R Frankenberger, J Shively,D Pascual,Mazdak Arabi,D Weinkauf, B Walker, A Spencer,Roger C Barr,
mag(2008)
Cited23Views0Bibtex
23
0
Heart Rhythmno. 7 (2007): 989
Load More
Author Statistics
#Papers: 76
#Citation: 2071
H-Index: 22
G-Index: 45
Sociability: 5
Diversity: 1
Activity: 0
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn