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个人简介
Research in the Andrade lab focuses on on the mechanisms underlying neuronal communication/synaptic transmission in the brain. Specifically our work seeks to elucidate the molecular mechanisms whereby neurotransmitters acting via G protein coupled receptors (GPCRs) signal their responses in neurons of the central nervous system.
Over the years we have focused principally on GPCRs sensing serotonin and secondarily acetylcholine, primarily in hippocampus and prefrontal cortex. Initially our work relied on pharmacological approaches in combination with electrophysiology, when that was all that was available. More recently we have fused these with imaging, molecular and genetic approaches to elucidate the role of specific genes and proteins in generating the physiology of CNS neurons. Most recently, with the advent of optogenetics we have become very interested in the physiology of synapses using GPCRs, which is the natural extension in the physiological direction of our previous work. The long term goal of this effort is to contribute to a mechanistic understanding of the pathophysiology of mental disorders while simultaneously contributing to the development of better therapeutic approaches. We have been fortunate to have our work funded by the NIH, for which we are very grateful.
Over the years we have focused principally on GPCRs sensing serotonin and secondarily acetylcholine, primarily in hippocampus and prefrontal cortex. Initially our work relied on pharmacological approaches in combination with electrophysiology, when that was all that was available. More recently we have fused these with imaging, molecular and genetic approaches to elucidate the role of specific genes and proteins in generating the physiology of CNS neurons. Most recently, with the advent of optogenetics we have become very interested in the physiology of synapses using GPCRs, which is the natural extension in the physiological direction of our previous work. The long term goal of this effort is to contribute to a mechanistic understanding of the pathophysiology of mental disorders while simultaneously contributing to the development of better therapeutic approaches. We have been fortunate to have our work funded by the NIH, for which we are very grateful.
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Ensaios de Geografiano. 23 (2024)
Journal of Hypertensionno. Suppl 1 (2023): e447-e448
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IUPHAR/BPS guide to pharmacology CITEno. 1 (2023)
Journal of Hypertensionno. Suppl 1 (2023)
Circumscribere International Journal for the History of Science (2022): 14-25
Revista Brasileira de História da Ciênciano. 2 (2022): 358-377
O Teatro Transcendeno. 1 (2021)
Handbook of Behavioral Neuroscience (2020): 279-288
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#Papers: 101
#Citation: 7499
H-Index: 42
G-Index: 75
Sociability: 6
Diversity: 3
Activity: 0
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