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My research career has focused on the study of the molecular biology of the skin, initially from the point of view of basic science using mouse models and more recently focusing on the development of advanced therapies for the treatment of genetic diseases of the skin with a translational approach to the clinic. In my years of predoctoral work, I developed several transgenic mouse models related to skin carcinogenesis studies, including the role of egfr in the biology of hair follicles and skin carcinogenesis, studies of regulation of the cell cycle in the epidermis and models of angiogenesis in carcinogenesis. In my postdoctoral work at NIH (USA), which lasted for 6 years, I initially studied models of inflammation in mouse skin (Joseloff et al), and later in a second postdoc I worked on biochemistry of ubiquitination systems (Murillas et al) and I began to gain experience in homologous recombination techniques for the targeted modification of genes. After returning to the Ciemat as a senior postdoctoral researcher, my interest focused on gene therapy for skin diseases by gene replacement, which led me to carry out biosafety studies in human keratinocytes transduced with retroviral vectors, describing novel mechanisms of insertional mutagenesis, (Almarza et al, 2011). More recently, and taking advantage of my long-term experience in gene targeting technology, I have focused on implementing gene editing-mediated correction of mutations causing epidermolysis in primary cell cultures from patients. Once corrected the cells can be assembled in cutaneous equivalents useful for grafting, and therefore of clinical translation value. This line of research has been very productive and has led to one patent application and the orphan drug designation for RDEB to a biotech product based on the work described in one of these publications (Bonafont et al, 2019).
Research Interests
Papers共 54 篇Author StatisticsCo-AuthorSimilar Experts
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Irene Lara-Sáez,Ángeles Mencía, Enrique Recuero,Yinghao Li,Marta García,Marta Oteo,Marta I Gallego,Ana Belén Enguita, Diana de Prado-Verdún,Sigen A,Wenxin Wang,Ramón García-Escudero,
Proceedings of the National Academy of Sciences of the United States of Americano. 28 (2024): e2322917121-e2322917121
Journal of Investigative Dermatologyno. 5 (2023): S149-S149
Marta Garcia,Jose Bonafont, Jesus Martinez-Palacios, Rudan Xu,Giandomenico Turchiano, Stina Svensson,Adrian J. Thrasher,Fernando Larcher,Marcela Del Rio,Ruben Hernandez-Alcoceba,Marina Garin,Angeles Mencia,
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2022): 96-108
A. Mencia,J. Bonafont,R. Murillas, S. Modamio, A. Nystrom,G. Zambruno,B. Duarte,M. Del Río,S. Llames,F. Larcher
Molecular therapy : the journal of the American Society of Gene Therapyno. 6 (2021): 2008-2018
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#Papers: 46
#Citation: 1786
H-Index: 19
G-Index: 42
Sociability: 6
Diversity: 0
Activity: 0
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