Dr. Klein is an internationally renowned neuroimmunologist who oversees a basic and translational science research program focused on the pathogenesis of neuroinfectious diseases of the central nervous system (CNS). Studies in the Klein laboratory focus on cellular and molecular mechanisms that orchestrate inflammation and define its impact on CNS function during both viral and autoimmune encephalitides. Work in the Klein laboratory has defined novel roles for cytokines and chemokines in the regulation of blood-brain barrier permeability to arboviruses, protective versus pathogenic leukocytes, and in mechanisms of neurologic sequelae of neurotropic and neurovirulent viral infections such as impaired learning and memory. These studies have contributed to our understanding of normal CNS immune surveillance and its relationship to the wide range in inflammatory patterns observed during neuroinflammatory diseases, and identified therapeutic targets, which is much needed in an era where there is little to offer patients with these diseases.

Dr. Klein currently provides follow-up care for patients after hospitalization for neuroinfectious diseases and accepts referrals of patients who have neurological infectious diseases at the Infectious Diseases Clinic.