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个人简介
Dr. Wechsler-Reya's research focuses on the signals that control growth and differentiation in the cerebellum, and how these signals are dysregulated in the brain tumor medulloblastoma. As a postdoc, he demonstrated that Sonic hedgehog (Shh) is a critical mitogen for neuronal precursors in the cerebellum, and that mutations in the Shh pathway predispose to medulloblastoma by activating a mitogenic pathway that normally functions only in early development. Now in his own lab, he continues to study the relationship between brain development and brain tumor formation. His lab’s contributions include identifying N-myc as a key target of the Shh pathway in neuronal precursors and in tumor cells; discovering a novel population of neural stem cells in the neonatal cerebellum; demonstrating that both neuronal precursors and stem cells can serve as cells of origin for MB; and identifying a population of cancer stem cells that is critical for propagation of Shh-associated tumors. More recently, Dr. Wechsler-Reya and his group have begun developing new models of medulloblastoma and are using them to test novel therapeutic approaches. His work has garnered several awards, including a Kimmel Scholar Award, an Award for Excellence in Pediatrics Research from the Society for Neuro-Oncology and a Leadership Award from the California Institute for Regenerative Medicine (CIRM).
研究兴趣
论文共 169 篇作者统计合作学者相似作者
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Rishaan Kenkre,Owen Chapman,Jens Luebeck,Vineet Bafna,Robert Wechsler-Reya,Jill Mesirov,Lukas Chavez
Cancer Researchno. 6_Supplement (2024): 2271-2271
Cancer Researchno. 6_Supplement (2024): 5470-5470
Yijun Yang, Silvia Anahi Valdés-Rives,Qing Liu,Yuzhe Li,Jun Tan,Yinfei Tan,Christian A Koch,Yuan Rong,Steven R. Houser,Shuanzeng Wei,Kathy Q Cai,Sheue-yann Cheng,
bioRxiv the preprint server for biology (2024)
Cancer Researchno. 6_Supplement (2024): 2648-2648
Maxwell P. Gold,Winnie Ong, Andrew M. Masteller,David R. Ghasemi, Julie Anne Galindo,Noel R. Park,Nhan C. Huynh,Aneesh Donde,Veronika Pister, Raul A. Saurez,Maria C. Vladoiu,Grace H. Hwang,
Nature Communicationsno. 1 (2024): 270-270
Varun V. Prabhu,Neel S. Madhukar,Coryandar Gilvary,C. Leah B. Kline, Sophie Oster, Wafik S. El-Deiry,Olivier Elemento, Faye Doherty, Alexander VanEngelenburg,Jessica Durrant,Rohinton S. Tarapore,Sean Deacon,
crossref(2023)
Varun V. Prabhu,Neel S. Madhukar,Coryandar Gilvary,C. Leah B. Kline, Sophie Oster, Wafik S. El-Deiry,Olivier Elemento, Faye Doherty, Alexander VanEngelenburg,Jessica Durrant,Rohinton S. Tarapore,Sean Deacon,
crossref(2023)
Duygu Kuzuoglu-Ozturk,Ozlem Aksoy,Christin Schmidt, Robin Lea,Jon D. Larson,Ryan R.L. Phelps,Nicole Nasholm, Megan Holt, Adrian Contreras,Miller Huang,Shannon Wong-Michalak,Hao Shao,
crossref(2023)
Varun V. Prabhu,Neel S. Madhukar,Coryandar Gilvary,C. Leah B. Kline, Sophie Oster, Wafik S. El-Deiry,Olivier Elemento, Faye Doherty, Alexander VanEngelenburg,Jessica Durrant,Rohinton S. Tarapore,Sean Deacon,
crossref(2023)
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