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During the past 35+ years, most of the work in the laboratory has been concerned with the neurobiology of quinolinate (QUIN) and kynurenate (KYNA), two metabolically related brain constituents with neuroexcitatory (and excitotoxic) and neuroinhibitory (and neuroprotective) properties, respectively. Both QUIN and KYNA are products of the kynurenine pathway of tryptophan degradation. Using a combination of biochemical, histological, behavioral and electrophysiological techniques, we have elaborated many of the characteristics and control mechanisms which govern the function of QUIN and KYNA in the brain. Ongoing in vivo and in vitro studies are designed 1) to identify possible abnormalities in kynurenine pathway metabolism in major neurological and psychiatric diseases, and in relevant animal models; 2) to further define the neurobiology of QUIN and KYNA in animals by manipulating the kynurenine pathway pharmacologically and genetically; and 3) to develop and use novel kynurenergic drugs in order to normalize functional impairments in the central nervous system. My laboratory currently consists of 8 team members (senior/postdoctoral scientists, students and research assistants), who focus mainly on work with experimental animals and on studies with clinical samples provided by investigators at my own institution and by selected external collaborators.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 7 (2024): 3679
Korrapati V Sathyasaikumar, Tonali Blanco-Ayala, Yiran Zheng, Lilly Schwieler, Sophie Erhardt, Maximilian Tufvesson-Alm,Burkhard Poeggeler,Robert Schwarcz
International journal of tryptophan research : IJTR (2024): 11786469241262876-11786469241262876
Biochemical pharmacologypp.116350-116350, (2024)
NEUROPSYCHOPHARMACOLOGY (2022): 361-362
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