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个人简介
Dr Sladek's scientific contributions centre on establishing the role of gene transcription networks in complex traits. He identified key physiological roles for the orphan nuclear receptor ERRalpha in regulating the balance between lipolysis and lipogenesis and ERRbeta in regulating development of the chorion and trophoblast. He has developed methods to identify transcriptional networks de novo in panels of recombinant congenic mouse strains and to characterize transcriptional effects of cis-regulatory genetic variants that underlie complex genetic traits. Most recently, he collaborated with Drs Froguel, Polychronakos, Posner and Prentki to complete the first genome-wide association study (GWAS) to identify risk loci for type 2 diabetes.
研究兴趣
论文共 168 篇作者统计合作学者相似作者
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Soo Heon Kwak, Ryan B Hernandez-Cancela,Daniel A DiCorpo,David E Condon,Jordi Merino,Peitao Wu,Jennifer A Brody,Jie Yao,Xiuqing Guo,Fariba Ahmadizar,Mariah Meyer,Murat Sincan,
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDSno. 3 (2024): 159461-159461
Soo Heon Kwak, Ryan B. Hernandez-Cancela,Daniel A DiCorpo,David E. Condon,Jordi Merino,Peitao Wu,Jennifer A Brody,Jie Yao,Xiuqing Guo,Fariba Ahmadizar,Mariah Meyer,Murat Sincan,
crossref(2024)
Soo Heon Kwak, Ryan B Hernandez-Cancela,Daniel A DiCorpo, David E Condon,Jordi Merino, Peitao Wu,Jennifer A Brody, Jie Yao,Xiuqing Guo, Fariba Ahmadizar,Mariah Meyer, Murat Sincan,
medRxiv : the preprint server for health sciences (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Sara M. Willems, Natasha Hui Jin Ng, Juan Carlos Delgado Fernández,Rebecca S. Fine,Eleanor Wheeler,Jennifer Wessel,Hidetoshi Kitajima,Gaëlle Marenne,Xueling Sim, Hanieh Yaghootkar,Shuai Wang,Sai Chen,
Wellcome open research (2023): 483-483
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The Lancet Diabetes & Endocrinologyno. 1 (2023): 3-4
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