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Research Interests
Role of the midline thalamus in learning and memory & affective behavior
Anatomy of the brainstem and limbic thalamus
Subcortical systems modulating the hippocampus, with a concentration on nucleus reuniens (RE) and the supramammillary nucleus (SUM) of the hypothalamus
Ascending brainstem-diencephalic-septohippocampal systems controlling states of the hippocampal EEG, theta and non-theta states
Functional interactions between the hippocampus, medial prefrontal cortex (mPFC) and the ventral midline thalamus
Anatomy and function of serotonergic systems of the brainstem, with specific attention to the median raphe nucleus
Role of the brainstem and midline thalamus in sleep/wake control, concentrating on the discharge properties of cells of nucleus reuniens and the paratenial nucleus during sleep/waking states in behaving rats
Function of sleep (NREM and REM), dispelling the hypothesis that sleep serves any role in the processing and consolidation of memories
Research Description
Early research of the lab centered on the description of ascending brainstem-diencephalic-septohippocampal systems responsible for controlling of states of the hippocampal EEG, principally the theta rhythm, and the functional significance of theta. We defined a complex circuitry involved in the generation of theta and non-theta states of the hippocampus, with direct relevance to memory-associated functions of the hippocampus. In recent years, we have focused on an examination of the anatomical, physiological and behavioral properties of nuclei of the midline thalamus, particularly the nucleus reuniens (RE). The nucleus reuniens is intimately interconnected with limbic cortical systems, foremost with the hippocampus and the medial prefrontal cortex (mPFC). Nucleus reuniens serves as a critical anatomical/functional bridge between the hippocampus and mPFC, directly involved in functions associated with both structures. Having defined the anatomical circuitry of nucleus reuniens (and other nuclei of the midline thalamus), we have recently demonstrated, in a series of behavioral studies, a critical role for RE in affective behavior, spatial working memory and executive functions. Further, we described a subset of cells of nucleus reuniens that discharge selectively in waking and REM sleep in behaving rats which appear to serve as an “attentional signal” to the hippocampus, in learning and memory. A current focus, using wide-ranging techniques including novel Cre+ rat strains, involves an examination of serotonergic effects on the limbic thalamus in affect and cognition.
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Current Opinion in Behavioral Sciences (2024): 101377
Nature communicationsno. 1 (2023): 4326-15
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bioRxiv (2022)
JOURNAL OF COMPARATIVE NEUROLOGYno. 2 (2022): 217-237
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