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Clostridium difficile is the most common cause of antibiotic-associated diarrhea. It’s a highly antibiotic resistant pathogen that can cause severe disease following antibiotic-mediated disruption of the protective gut microbiota.
The aim of our research is to understand the molecular basis of interactions between the bacterium and its host. We study the outermost layer of the C. difficile cell envelope, the surface- or S-layer, a 2-dimensional proteinaceous crystal that completely coats the surface of the bacterium.
The S-layer has been implicated in adhesion and induction of innate immunity. Our work combines molecular microbiology and structural biology to study S-layer biogenesis and function.
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论文共 47 篇作者统计合作学者相似作者
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Nicola F. Galley,Darren Greetham, Marcel G. Alamán-Zárate,Mike P. Williamson,Caroline A. Evans,William D. Spittal, Jessica E. Buddle,Jane Freeman,Georgina L. Davis,Mark J. Dickman,Mark H. Wilcox,Andrew L. Lovering,
Journal of Biological Chemistryno. 1 (2024): 105529-105529
Wichuda Phothichaisri,Tanaporn Phetruen,Surang Chankhamhaengdecha,Tavan Janvilisri,Puey Ounjai,Robert P Fagan,Sittinan Chanarat
Methods in molecular biology (Clifton, N.J.) (2024): 245-262
bioRxiv (Cold Spring Harbor Laboratory) (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Alexia L.M. Royer, Andrew A. Umansky, Marie-Maude Allen,Julian R. Garneau,Maicol Ospina-Bedoya,Joseph A. Kirk,Gregory Govoni,Robert P. Fagan,Olga Soutourina,Louis-Charles Fortier
crossref(2022)
Michael J. Ormsby,Filipa Vaz,Joseph A. Kirk,Anna Barwinska-Sendra, Jennifer C. Hallam, Paola Lanzoni-Mangutchi,John Cole,Roy R. Chaudhuri,Paula S. Salgado,Robert P. Fagan,Gillian R Douce
bioRxiv (Cold Spring Harbor Laboratory) (2022)
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