His main research interests include the treatment of acute stroke, health care organisation, stroke care logistics, and raising stroke awareness. He has developed a training program that uses a simulation environment to improve decision-making and logistics of stroke teams when administering intravenous thrombolysis. In 2015, Prof. Mikulik and his team established the RES-Q Registry of Stroke Care Quality. Robert Mikulik served as a Member at Large on the Executive Committee in the European Stroke Organization from 2016 to 2017, and he chaired the ESO-EAST project, which aimed to improve stroke care in Central and Eastern European countries.