基本信息
views: 56
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Research interests
Pharmacological investigations in cancer and other diseases conducted in vitro and in vivo, included a variety of anticancer agents, e.g. novel anthracyclines, the biochemical modulation of 5-fluorouracil focusing on the stereospecific pharmacokinetics of folates in patients with colorectal cancer and intratumoural pharmacokinetics of drugs using the microdialysis technique in close collaboration with the Department of Clinical Pharmacology. Always actively participating in clinical trials, molecular pharmacology and drug resistance mechanisms became a central part of research with a focus on a variety of cellular cancer models. For the time being, microRNA are investigated as regulatory molecules during the development of drug resistance and endothelial intravasation during metastasis formation, where exosomal microRNA function as “malignant” messengers between cells. Our contribution to the era of personalised medicine was the EXACT trail, where we were able to demonstrate the feasibility of this concept, which benefited patients without established treatment option in a huge team effort.
Pharmacological investigations in cancer and other diseases conducted in vitro and in vivo, included a variety of anticancer agents, e.g. novel anthracyclines, the biochemical modulation of 5-fluorouracil focusing on the stereospecific pharmacokinetics of folates in patients with colorectal cancer and intratumoural pharmacokinetics of drugs using the microdialysis technique in close collaboration with the Department of Clinical Pharmacology. Always actively participating in clinical trials, molecular pharmacology and drug resistance mechanisms became a central part of research with a focus on a variety of cellular cancer models. For the time being, microRNA are investigated as regulatory molecules during the development of drug resistance and endothelial intravasation during metastasis formation, where exosomal microRNA function as “malignant” messengers between cells. Our contribution to the era of personalised medicine was the EXACT trail, where we were able to demonstrate the feasibility of this concept, which benefited patients without established treatment option in a huge team effort.
Research Interests
Papers共 392 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Thomas Bartl,Christoph Grimm,Robert M. Mader,Christoph Zielinski,Gerald Prager,Matthias Unseld, Merima Herac-Kornauth,Alessandro Antonio Buda, Francesco Fanfani
Journal of personalized medicineno. 8 (2023): 1186-1186
FRONTIERS IN CARDIOVASCULAR MEDICINE (2023): 1030842-1030842
crossref(2023)
crossref(2023)
ESC heart failureno. 6 (2023): 3559-3572
The Lancetno. 10394 (2023): 2138-2147
Gastroenterologyno. 7 (2022): 1815-1821
Cited0Views0Bibtex
0
0
Load More
Author Statistics
#Papers: 394
#Citation: 4777
H-Index: 38
G-Index: 59
Sociability: 7
Diversity: 3
Activity: 23
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn