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Our research focuses on understanding the molecular mechanisms that regulate DNA replication and cell proliferation during animal development. An orderly process of events called the cell cycle, which in its most familiar form consists of four phases (G1-S-G2-M) controls cell proliferation. The genome is replicated during the “S” or synthesis phase and duplicated chromosomes are segregated to daughter cells during the “M” or mitotic phase when cell division occurs. G1 and G2 are “gap” phases during cells regulate the entry into S phase and M phase, respectively. We study gene expression events that control how cells make the decision to enter S phase and proliferate, or to exit the cell cycle and differentiate. Without such control there would be no coordination between cell proliferation and the development and function of the many different types of tissues that make up an organism. In addition, the breakdown of cell cycle regulation is one of the events that contribute to the generation of cancer.
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bioRxiv : the preprint server for biology (2024)
NUCLEUSno. 1 (2023): 2293604-2293604
Evgeniya N Andreyeva, Alexander V Emelyanov,Markus Nevil, Lu Sun,Elena Vershilova,Christina A Hill, Michael-C Keogh,Robert J Duronio,Arthur I Skoultchi,Dmitry V Fyodorov
crossref(2022)
Harmony R Salzler, Vasudha Vandadi, Benjamin D McMichael,John C Brown, Sally A Boerma,Mary P Leatham-Jensen, Kirsten M Adams,Michael P Meers, Jeremy M Simon,Robert J Duronio, Daniel J McKay,A Gregory Matera
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