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个人简介
As a virologist, I have studied the mechanisms of evolution of influenza viruses including genetic drift and shift and the emergence of pandemic influenza viruses. In collaboration with the World Health Organization, my laboratory established that the wild aquatic birds of the world, including wild ducks and shorebirds, are the natural reservoirs of influenza viruses. Our studies have revealed geographically separable lineages of influenza viruses, including those in Eurasia and the Americas, and evolutionary statis in their reservoir species. Emergence of the Asian-57 and Hong Kong-68 human pandemics involved reassortment between influenza viruses from the Eurasian avian lineage and influenza viruses circulating in humans. After interspecies transfer, the influenza virus genes evolve rapidly. The molecular events involved in the emergence of highly pathogenic avian H5 influenza viruses are associated with the hemagglutinin cleavage site and can be influenced by the presence of carbohydrate residues. More recently, I have been involved in elucidating the origin of the avian H5N1 influenza viruses that transmitted directly to humans in Hong Kong and killed six of eighteen humans infected. Live poultry markets in Hong Kong were the source of these viruses, and the molecular changes that permitted interspecies transmission are now being resolved.
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Mohamed E El Zowalaty, Jennifer DeBeauchmp,Trushar Jeevan,John Franks,Kimberly Friedman, Rina Pretorius,Sean G Young,Robert G Webster,Richard J Webby
Wen Su, Rhodri Harfoot, Yvonne Su,Jennifer DeBeauchamp,Udayan Joseph,Jayanthi Jayakumar,Jeri-Carol Crumpton,Trushar Jeevan,Adam Rubrum,John Franks, Philippe Pascua, Christina Kackos,
Research Square (Research Square) (2021)
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