基本信息
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Career Trajectory
Bio
A new frontier in bioenergetics concerns the biogenesis of electron transport complexes, including the orchestrated insertion of critical cofactors. Cytochrome c biogenesis has itself become an excellent model for the intracellular transport of the heme cofactor, control of heme red-ox state, and covalent attachment of heme to the apocytochrome (at a conserved CXXCH motif via thioether bonds). Three pathways (called systems I, II, III) are used to assemble c-type cytochromes (see Fig 1). Prokaryotes (and plants) use system I or II, while mitochondria of fungi to humans use system III. We pursue long-standing studies on the discovery and mechanisms of cytochrome c biogenesis. We have engineered each system to function in Escherichia coli, and we have purified all proteins of each system from E. coli membranes, facilitating an understanding of the molecular mechanisms of biogenesis.
Understanding systems I, II, and III at the deep level will enable the discovery of chemicals (antibiotics) that specifically target the bacterial systems, thus impacting infectious diseases like tuberculosis, meningitis, and other respiratory and inflammatory illnesses. The system III mitochondrial pathway (HCCS) is mutated in human microphthalmia with linear skin defects (MLS) so we will further understand the basis for this disease.
Understanding systems I, II, and III at the deep level will enable the discovery of chemicals (antibiotics) that specifically target the bacterial systems, thus impacting infectious diseases like tuberculosis, meningitis, and other respiratory and inflammatory illnesses. The system III mitochondrial pathway (HCCS) is mutated in human microphthalmia with linear skin defects (MLS) so we will further understand the basis for this disease.
Research Interests
Papers共 44 篇Author StatisticsCo-AuthorSimilar Experts
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The Journal of biological chemistryno. 11 (2023): 105332-105332
Jiao Li,Wan Zheng,Ming Gu,Long Han,Yanmei Luo,Koukou Yu,Mengxin Sun,Yuliang Zong, Xiuxiu Ma, Bing Liu,Ethan P. Lowder,Deanna L. Mendez,
Molly C Sutherland,Deanna L Mendez,Shalon E Babbitt,Dustin E Tillman, Olga Melnikov,Nathan L Tran, Noah T Prizant,Andrea L Collier,Robert G Kranz
Molly C Sutherland,Deanna L Mendez,Shalon E Babbitt,Dustin E Tillman, Olga Melnikov,Nathan L Tran, Noah T Prizant,Andrea L Collier,Robert G Kranz
crossref(2021)
Journal of Molecular Biologyno. 8 (2018): 1065-1080
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