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Bio
Dr. Ferris's research is focused on cellular immune mechanisms of natural killer (NK) cell, dendritic cells (DC) and T lymphocyte activation against head and neck cancer (HNC) tumor antigens. In addition his group pioneered studies demonstrating innate and adaptive immune responses induced by EGFR-specific mAb, cetuximab in cancer patients. His laboratory also investigates the role of immunosuppressive molecules, such as immune checkpoint receptors, including PD-1, CTLA-4, TIM-3, and LAG-3. His laboratory is funded by NCI R01 and SPORE grants. He is PI for multiple phase I, II, and III immunotherapeutic trials, and the Ferris laboratory is analyzing peripheral blood and tumor infiltrating lymphocyte specimens to identify biomarkers of response in treated patients. The laboratory is also focused on mechanisms of tumor antigen processing and immunologic evasion used by head and neck cancer cells, themselves. New trials are testing combination immunotherapies, through 1-month, "window of opportunity" neoadjuvant clinical trials, providing novel and unique pre- and post-treatment specimens to interrogate the tumor microenvironment (TME) for factors that drive personalized cancer immunotherapy.
Research Interests
Papers共 1056 篇Author StatisticsCo-AuthorSimilar Experts
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JOURNAL FOR IMMUNOTHERAPY OF CANCERno. 3 (2024)
Aparna Rao,Xiaoran Zhang,Anthony R. Cillo,Jonathan H. Sussman,Poorva Sandlesh, Antonio Corral Tarbay,Arka N. Mallela,Carly Cardello,Katharine Krueger, Jessica Xu, Alex Li,Jason Xu,
biorxiv(2024)
Head & neckno. 6 (2024): 1253-1262
Laryngo- rhino- otologieno. S 01 (2024): S167-S187
ORAL ONCOLOGY (2024): 106703-106703
CANCER (2024)
Laryngo-Rhino-Otologieno. S 01 (2024)
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