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个人简介
Dr. Ferris's research is focused on cellular immune mechanisms of natural killer (NK) cell, dendritic cells (DC) and T lymphocyte activation against head and neck cancer (HNC) tumor antigens. In addition his group pioneered studies demonstrating innate and adaptive immune responses induced by EGFR-specific mAb, cetuximab in cancer patients. His laboratory also investigates the role of immunosuppressive molecules, such as immune checkpoint receptors, including PD-1, CTLA-4, TIM-3, and LAG-3. His laboratory is funded by NCI R01 and SPORE grants. He is PI for multiple phase I, II, and III immunotherapeutic trials, and the Ferris laboratory is analyzing peripheral blood and tumor infiltrating lymphocyte specimens to identify biomarkers of response in treated patients. The laboratory is also focused on mechanisms of tumor antigen processing and immunologic evasion used by head and neck cancer cells, themselves. New trials are testing combination immunotherapies, through 1-month, "window of opportunity" neoadjuvant clinical trials, providing novel and unique pre- and post-treatment specimens to interrogate the tumor microenvironment (TME) for factors that drive personalized cancer immunotherapy.
研究兴趣
论文共 993 篇作者统计合作学者相似作者
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JOURNAL FOR IMMUNOTHERAPY OF CANCERno. 3 (2024)
Aparna Rao,Xiaoran Zhang, Anthony R. Cillo,Jonathan H. Sussman, Poorva Sandlesh, Antonio Corral Tarbay,Arka N. Mallela, Carly Cardello,Katharine Krueger, Jessica Xu, Alex Li, Jason Xu,
biorxiv(2024)
Xavier Liem,Thierry de Baere, Omar I. Vivar, Tanguy Y. Seiwert,Colette Shen, Zsuzsanna Papai,Victor Moreno, Zoltan Takacsi-Nagy, Frigyes Helferich,Juliette Thariat, Zhen Gooi,Sue S. Yom,
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2024)
Robert L. Ferris,Hisham Mehanna,Jonathan D. Schoenfeld,Makoto Tahara,Sue S. Yom,Robert Haddad, Andre Koenig, Pauline Witzler,Marcis Bajars,Christophe Le Tourneau
Laryngo- rhino- otologieno. S 01 (2024): S167-S187
ORAL ONCOLOGY (2024): 106703-106703
CANCER (2024)
Laryngo-Rhino-Otologieno. S 01 (2024)
Jason Luke, Rebekah Dadey,Ryan Augustin,Sarah Newman, Krishna Singh, Rose Doerfler, Sarah Behr,Patrice Lee, Brian Isett, Christopher Deitrick,Aofei Li,Marion Joy,
Research square (2023)
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