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Bio
Robert Edwards is a neuroscientist known for his work on the molecular and cellular basis of neurotransmitter release and its role in Parkinson's disease. His group identified the proteins that transport classical transmitters into neurosecretory vesicles, characterizing their role in quantal release, their mechanism and their regulation as well as their structure. Using the transporters, he helped to establish the phenomenon of neurotransmitter corelease: his lab recently showed that individual neurons can release two transmitters with different frequency dependence, and the two vesicle populations recycle through distinct mechanisms. He has also used the transporters to elucidate the formation of dense core vesicles that mediate regulated release of peptides. Since the original identification of a vesicular monoamine transporter by selection in MPP+, his work has focused on the pathogenesis of Parkinson’s disease and most recently the function of presynaptic protein -synuclein, which has a central, causative role in the disorder. He also identified the first opioid receptor (delta-) and the transporters involved in glutamate recycling. The work in his lab has implications for behavior and neural degeneration, in particular Parkinson's disease.
Research Interests
Papers共 405 篇Author StatisticsCo-AuthorSimilar Experts
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Experimental Neurology (2024): 114668-114668
JOURNAL OF IMMUNOLOGYno. 4 (2024): 576-585
EXPERIMENTAL NEUROLOGY (2024)
Frontiers in immunology (2024): 1343716-1343716
FRONTIERS IN IMMUNOLOGY (2024)
Frontiers in Immunology (2024)
Jacqueline Burré,Robert H Edwards,Glenda Halliday,Anthony E Lang,Hilal A Lashuel,Ronald Melki, Shigeo Murayama,Tiago F Outeiro,Stella M Papa,Leonidas Stefanis,Amanda L Woerman, Dalton James Surmeier,
Movement disorders : official journal of the Movement Disorder Society (2024)
Cellno. 1 (2024): 79-94.e24
Boyang Zhao, Zhongzheng Cao, Yi Zheng,Phuong Nguyen,Alisa Bowen,Robert H Edwards,Robert M Stroud, Yi Zhou, Menno Van Lookeren Campagne,Fei Li
Nature communicationsno. 1 (2024): 5388-5388
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