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Dr. Robert Tigelaar's major research focus continues to be the dendritic epidermal d T cells (DETC) populating the skin of all normal strains of mice. A number of longstanding collaborations between the Tigelaar lab and those of Michael Girardi (Dermatology) and Adrian Hayday (Guy’s Immunobiology [London]) include:
The generation and characterization of a Vg5-/- “knockout” mouse selectively deficient in DETCs expressing the TCR prototypically seen on >95% of such cells; studies of such mice unexpectedly showed that in the absence of Vg5, the replacement population of d DETC includes a significant number of cells expressing a Vd1/d1 TCR with a similar 3-D conformation as the conventional Vg5/Vd1 TCR (as defined by an anti-clonotypic antibody to the Vg5/Vd1 TCR);
Documentation that some (e.g., FVB and NOD), but not other (B6) strains of mice genetically deficient in d T cells (d-/- mice) develop a localized (ears) cutaneous inflammation/ spontaneous dermatitis (SpD) that is dependent (like atopic dermatitis) both upon conventional aß T cells and upon an appropriate external environment.
The generation and characterization of a Vg5-/- “knockout” mouse selectively deficient in DETCs expressing the TCR prototypically seen on >95% of such cells; studies of such mice unexpectedly showed that in the absence of Vg5, the replacement population of d DETC includes a significant number of cells expressing a Vd1/d1 TCR with a similar 3-D conformation as the conventional Vg5/Vd1 TCR (as defined by an anti-clonotypic antibody to the Vg5/Vd1 TCR);
Documentation that some (e.g., FVB and NOD), but not other (B6) strains of mice genetically deficient in d T cells (d-/- mice) develop a localized (ears) cutaneous inflammation/ spontaneous dermatitis (SpD) that is dependent (like atopic dermatitis) both upon conventional aß T cells and upon an appropriate external environment.
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Michael Girardi, David E Oppenheim, Carrie R Steele,Julia M Lewis,Earl Glusac,Renata Filler, Paul Hobby,Brian Sutton,Robert E Tigelaar,Adrian C Hayday
Journal of immunology (Baltimore, Md. : 1950)no. 9 (2018): 3031-3035
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Journal of Clinical Immunologyno. 4 (2011): 666-680
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