基本信息
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Bio
Cancer is typically considered a genetic disease. However, recent progress in our understanding of epigenetic aberrations in cancer has challenged this view. Overarching goal of Faryabi lab is to understand epigenetic mechanisms of transcriptional addiction in cancer and exploit this information to advance cancer therapeutics.
To pursue this objective, we use cutting-edge chromatin conformation capture, high-content imaging, single-cell epigenomics, functional genomics, and combine these technologies with our expertise in computational sciences to systematically explore: i) how epigenetic control of gene expression is disrupted in cancer, ii) why transcriptional addiction can develop, and iii) how heterogeneity and plasticity of transcriptional dependencies enable drug resistance.
To pursue this objective, we use cutting-edge chromatin conformation capture, high-content imaging, single-cell epigenomics, functional genomics, and combine these technologies with our expertise in computational sciences to systematically explore: i) how epigenetic control of gene expression is disrupted in cancer, ii) why transcriptional addiction can develop, and iii) how heterogeneity and plasticity of transcriptional dependencies enable drug resistance.
Research Interests
Papers共 61 篇Author StatisticsCo-AuthorSimilar Experts
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Aanchal Mongia, Fatema Tuz Zohora, Noah G. Burget,Yeqiao Zhou,Diane C. Saunders,Yue J. Wang,Marcela Brissova,Alvin C. Powers,Klaus H. Kaestner,Golnaz Vahedi,Ali Naji,Gregory W. Schwartz,
NATURE COMMUNICATIONSno. 1 (2024): 3744-3744
Brent S Perlman, Noah Burget,Yeqiao Zhou,Gregory W Schwartz,Jelena Petrovic,Zora Modrusan,Robert B Faryabi
bioRxiv : the preprint server for biology (2024)
Nature Metabolismno. 5 (2023): 713-715
Naomi Goldman,Aditi Chandra,Isabelle Johnson, Matthew A. Sullivan,Abhijeet R. Patil,Ashley Vanderbeck, Atishay Jay,Yeqiao Zhou,Emily K. Ferrari,Leland Mayne,Jennifer Aguilan,Hai-Hui Xue,
Abhijeet R. Patil,Jonathan Schug,Chengyang Liu, Deeksha Lahori,Hélène C. Descamps, the Human Pancreas Analysis Consortium,Ali Naji,Klaus H. Kaestner,Robert B. Faryabi,Golnaz Vahedi
biorxiv(2023)
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Author Statistics
#Papers: 62
#Citation: 1990
H-Index: 22
G-Index: 42
Sociability: 6
Diversity: 3
Activity: 146
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