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职业迁徙
个人简介
As a virologist I study the replication and biology of two groups of enveloped viruses, influenza viruses and paramyxoviruses. These viruses are being studied not only because of their importance to human and animal health but also because they are excellent models for understanding a variety of properties of integral membrane proteins. As the viral integral proteins are the major antigenic determinants of the viruses, knowledge about their structure should enhance our understanding of how to develop new vaccines. In addition, some of the biochemical activities of the viruses are essential to the virus, making them attractive as points of intervention in the virus life cycle to which rationally designed therapeutic agents can be developed. Several different projects are under study: (1) Understanding the mechanism by which viruses enter cells by virus-mediated membrane fusion. Both influenza viruses and paramyxoviruses encode glycoproteins that are molecular machines that undergo a cascade of controlled conformational changes leading to the coalescence of the viral membrane with a cellular membrane; (2) The protein-protein interactions necessary for virus assembly and the role of lipid raft microdomains in this process; (3) The structure and function of the minimalistic protein-selective influenza virus-encoded ion channels, M2 and BM2; (4) Endocytosis and degradations signals in viral glycoproteins; (5) The interaction of multifunctional viral proteins with cellular proteins to control both the cell cycle and antagonize the cellular innate immune system; (6) Using reverse genetics to understand viral pathogenesis. We use a multidisciplinary approach using techniques from molecular biology, cell biology, genetics, biochemistry and structural biology (X-ray crystallography and NMR) to address these questions.
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