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Bio
Dr. Holt’s work is focused on the structural diversity of T cell and B cell receptors which enable our bodies to discriminate our own healthy cells from cells that are mutated or infected by a pathogen. His group is focused on exploiting our knowledge of T cell and B cell receptors to genetically engineer immune cells to treat cancer.
Another branch of Dr. Holt’s work concerns the relationship between pathogens and cancer; their work in colorectal carcinomas revealed a strong link between colorectal carcinoma and infection with the bacteria Fusobacterium nucleatum, and his lab is currently working on developing a vaccine against this pathogen.
Another branch of Dr. Holt’s work concerns the relationship between pathogens and cancer; their work in colorectal carcinomas revealed a strong link between colorectal carcinoma and infection with the bacteria Fusobacterium nucleatum, and his lab is currently working on developing a vaccine against this pathogen.
Research Interests
Papers共 354 篇Author StatisticsCo-AuthorSimilar Experts
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Trends in Pharmacological Sciencesno. 5 (2024): 406-418
APPLIED PHYSICS LETTERSno. 5 (2023)
bioRxiv the preprint server for biology (2023)
eLife (2023)
E. Titmuss, K. Milne, M. R. Jones,T. Ng, J. T. Topham,S. D. Brown,D. F. Schaeffer,S. Kalloger,D. Wilson,R. D. Corbett,L. M. Williamson,K. Mungall,
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