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Robert Edwards is a neuroscientist known for his work on the molecular and cellular basis of neurotransmitter release and its role in Parkinson's disease. His group identified the proteins that transport classical transmitters into neurosecretory vesicles, characterizing their role in quantal release, their mechanism and their regulation as well as their structure. Using the transporters, he helped to establish the phenomenon of neurotransmitter corelease: his lab recently showed that individual neurons can release two transmitters with different frequency dependence, and the two vesicle populations recycle through distinct mechanisms. He has also used the transporters to elucidate the formation of dense core vesicles that mediate regulated release of peptides. Since the original identification of a vesicular monoamine transporter by selection in MPP+, his work has focused on the pathogenesis of Parkinson’s disease and most recently the function of presynaptic protein -synuclein, which has a central, causative role in the disorder. He also identified the first opioid receptor (delta-) and the transporters involved in glutamate recycling. The work in his lab has implications for behavior and neural degeneration, in particular Parkinson's disease.
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Experimental Neurology (2024): 114668-114668
EXPERIMENTAL NEUROLOGY (2024)
Natureno. 7972 (2023): 181-191
Antoni Kowalski,Cristine Betzer, Sigrid Thirup Larsen,Emil Gregersen,Estella A. Newcombe,Montaña Caballero Bermejo, Viktor Wisniewski Bendtsen,Jorin Diemer, Christina V Ernstsen,Shweta Jain, Alicia Espiña Bou,Annette Eva Langkilde,
The EMBO Journal (2023)
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Samir Batarni, Nanda Nayak, Audrey Chang,Fei Li, Surabhi Hareendranath, Lexi Zhou,Hongfei Xu,Robert Stroud,Jacob Eriksen,Robert H Edwards
Antoni Kowalski,Cristine Betzer, Sigrid Thirup Larsen,Emil Gregersen,Estella A. Newcombe,Montana Caballero Bermejo, Viktor Wisniewski Bendtsen,Jorin Diemer, Christina Ernstsen,Shweta Jain, Alicia Espina Bou,Annette Eva Langkilde,
EMBO JOURNAL (2023)
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Antoni Kowalski,Cristine Betzer, Sigrid Thirup Larsen,Emil Gregersen,Estella A Newcombe,Montaña Caballero Bermejo, Viktor Wisniewski Bendtsen,Jorin Diemer, Christina V Ernstsen,Shweta Jain, Alicia Espiña Bou,Annette Eva Langkilde,
biorxiv(2023)
NPJ Parkinson's diseaseno. 1 (2023): 47-2
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