基本信息
浏览量:8
职业迁徙
个人简介
Research Overview
Theoretical/Computational Studies of Structure/Function Relations in Nanopores:
The Nuclear Pore Complex.
The Nuclear Pore Complex (NPC) perforates the nuclear membrane and allows the flow of large biomolecules between the nucleoplasm and the cytoplasm in eukaryotic cells. It is the largest protein complex in the cell. Its detailed structure has not yet been fully elucidated, but it is known that the pore region is lined with natively unfolded nucleoporin proteins. These proteins extend into the center of the pore in a polymer brush configuration. They form a tight barrier to the passage of large biomolecules. The amino acid sequence of the natively unfolded nucleoporins includes hydrophobic repeat segments. These hydrophobic segments bind transiently to hydrophobic grooves on the outside of special globular receptor proteins (Nuclear Transport Factors [NTFs]), which also bind biomolecules (“cargoes”) waiting to be transported into/out of the nucleus. Transient binding of the nucleoporin (nup) strands to the receptor protein NTFs allows the NTFs (with cargo attached) to transport through the NPC in a selective and efficient way. The exact mechanism of the transport process is not known. We use coarse-grained models to investigate basic physico-chemical models of NPC function. These include bead-spring models of the nup chains that are grafted to the inside of the NPC pore and interact with spherical NTFs. Coarse-grained MD simulations of these systems yield insight into the way the receptor proteins interact with the nup filiaments, such as inducing morphology changes in the nup brush and diffusing through the brush barrier from one side of the NPC to the other. In addition, coarse-grained statistical mechanical models including Flory-Huggins and Self-Consistent Field Theories are utilized to assess trends in relevant equilibrium aspects of NPC function.
研究兴趣
论文共 123 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
PHYSICAL REVIEW Ano. 4 (2019): 043617
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn