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个人简介
I lead the University of Oxford's programme of research into the inflammatory neuropathies.
Guillain-Barré syndrome (GBS) is a devastating, acute inflammatory neuropathy with substantial mortality as well as morbidity. There is an urgent need to improve upon the current situation where 4-5% of GBS patients die, 20-25% require mechanical ventilation, 14-20% have severe disability at 1 year, and many more are left with residual weakness, persistent pain and/or are unable to resume their former occupation.
Chronic inflammatory demyelinating polyradiculo-neuropathy (CIDP) and multifocal motor neuropathy (MMN) are chronic inflammatory neuropathies which produce significant long-term and often progressive disability with a sizeable economic cost.
Despite this, disease modifying therapies for these conditions have not advanced in over 20 years, the pathological mechanisms driving them are incompletely characterised, and there is no reliable way to identify early those patients who respond poorly to standard treatments and are thus most likely to benefit from additional therapy.
Guillain-Barré syndrome (GBS) is a devastating, acute inflammatory neuropathy with substantial mortality as well as morbidity. There is an urgent need to improve upon the current situation where 4-5% of GBS patients die, 20-25% require mechanical ventilation, 14-20% have severe disability at 1 year, and many more are left with residual weakness, persistent pain and/or are unable to resume their former occupation.
Chronic inflammatory demyelinating polyradiculo-neuropathy (CIDP) and multifocal motor neuropathy (MMN) are chronic inflammatory neuropathies which produce significant long-term and often progressive disability with a sizeable economic cost.
Despite this, disease modifying therapies for these conditions have not advanced in over 20 years, the pathological mechanisms driving them are incompletely characterised, and there is no reliable way to identify early those patients who respond poorly to standard treatments and are thus most likely to benefit from additional therapy.
研究兴趣
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European journal of neurologyno. 8 (2024): e16365-e16365
Brain communicationsno. 4 (2024): fcae163-fcae163
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRYpp.jnnp-2024, (2024)
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRYno. 2 (2024): 114-124
Kaminie Moodley, Anandan A Moodley,Stephanie Efthymiou, Henry Houlden,Pierre L A Bill,Vinod B Patel,Simon Rinaldi
Practical neurology (2024)
Rachel E Harris,Mark Atherton,Johann Te Water Naude, Georgina A Bird-Lieberman,Sithara Ramdas,Janev Fehmi,Simon Rinaldi, Min T Ong
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGYno. 8 (2023): 1118-1122
Journal of the Peripheral Nervous System (2023)
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