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Our Research
Neurological disorders include a range of progressive and largely untreatable conditions that are characterized by cellular degeneration in a region- and/or subtype-selective fashion. There is a great experimental need for renewable sources of clinically relevant and regionally defined subclasses of neurons and glia to understand the precise underlying molecular pathogenic events responsible for causing neurodegeneration.
Against this background, our lab focuses on two main themes:
1) Disease Modelling
In order to closely approximate human pathophysiology we integrate the human induced pluripotent stem cell (iPSC) technology together with developmentally rationalised directed differentiation strategies to generate clinically relevant and regionally defined populations of neurons and glia. This serves as an ideal experimental platform to interrogate early pathogenic events in a range of neurodegenerative disorders. The overarching focus of our laboratory is to uncover the precise roles of deregulated RNA metabolism and cellular autonomy in the pathogenesis of motor neuron disease (MND).
2) Developmental Neurobiology
A pre-requisite to harnessing the promise of the iPSC technology in Regenerative Medicine is a comprehensive understanding of cell type specific developmental lineage restriction programmes. We utilise ontogeny-recapitulating differentiation strategies to elucidate key events in neural lineage restriction, subsequent regional fate specification and functional maturation of diverse neuronal and glial subtypes.
Neurological disorders include a range of progressive and largely untreatable conditions that are characterized by cellular degeneration in a region- and/or subtype-selective fashion. There is a great experimental need for renewable sources of clinically relevant and regionally defined subclasses of neurons and glia to understand the precise underlying molecular pathogenic events responsible for causing neurodegeneration.
Against this background, our lab focuses on two main themes:
1) Disease Modelling
In order to closely approximate human pathophysiology we integrate the human induced pluripotent stem cell (iPSC) technology together with developmentally rationalised directed differentiation strategies to generate clinically relevant and regionally defined populations of neurons and glia. This serves as an ideal experimental platform to interrogate early pathogenic events in a range of neurodegenerative disorders. The overarching focus of our laboratory is to uncover the precise roles of deregulated RNA metabolism and cellular autonomy in the pathogenesis of motor neuron disease (MND).
2) Developmental Neurobiology
A pre-requisite to harnessing the promise of the iPSC technology in Regenerative Medicine is a comprehensive understanding of cell type specific developmental lineage restriction programmes. We utilise ontogeny-recapitulating differentiation strategies to elucidate key events in neural lineage restriction, subsequent regional fate specification and functional maturation of diverse neuronal and glial subtypes.
研究兴趣
论文共 126 篇作者统计合作学者相似作者
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Nature communicationsno. 1 (2024): 4819-4819
Autophagyno. 5 (2024): 1201-1202
Brain : a journal of neurologyno. 7 (2024): 2325-2333
Karishma D’Sa,Minee L. Choi,Aaron Z. Wagen,Núria Setó-Salvia,Olga Kopach,James R. Evans,Margarida Rodrigues, Patricia Lopez-Garcia, Ali Ghareeb, James Bayne,Melissa Grant-Peters,Sonia Garcia-Ruiz,
biorxiv(2024)
International review of neurobiology (2024): 381-450
BRAINno. 3 (2024): 970-979
Trends in neurosciencesno. 10 (2023): 879-892
Neuronno. 19 (2023): 3011-3027.e7
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