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Free-living cells navigate a challenging world using solitary solutions. In contrast, cells within a multicellular organism must act as a collective to carry out functions for the benefit of all. We study the unique and complex biology of cells in the context of tissues and organs. Model organisms such as the fruit fly Drosophila provide an unprecedented opportunity to understand the cell biology of multicellularity. Our lab uses a variety of high-throughput experimental tools such as genomics, genetics and quantitative imaging. We couple such data-intensive experiments with computational analysis and modeling. The goal is to gain a comprehensive and predictive understanding of how multicellular properties emerge from the collective of cells present in a tissue or organ. Such understanding has implications for diseases such as cancer, as well as methods of tissue regeneration to treat disease.
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论文共 62 篇作者统计合作学者相似作者
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Sha Qiao,Sebastian Bernasek,Kevin D. Gallagher, Jessica O'Connell, Shigehiro Yamada,Neda Bagheri,Luis A. N. Amaral,Richard W. Carthew
DEVELOPMENTno. 1 (2024)
Genetics (2024)
eLife (2024)
Developmentno. 8 (2023)
iScienceno. 10 (2022): 105097
TRENDS IN GENETICSno. 4 (2021): 389-400
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