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Bio
I have worked on many aspects of bioinformatics and statistical genetics, but much of my research since 2000 has concerned the statistical genetic analysis of populations - either animal or plant - descended from multiple inbred founders, often called Multi-Parent Populations (MPPs). MPP chromosomes are mosaics of the founders, and this observation can be used to investigate the genetic architecture of complex traits. These centre around how genetic variation at a locus is associated with a phenotype - for example whether it is caused by single or by multiple linked variants (Baud et al 2013 Nat Genet), and whether the parent-of-origin of an allele modulates its phenotypic effect (Mott et al 2015 Cell). To do this, I developed an analysis framework based on decomposing the genomes of individuals into probabilistic mosaics of the population founders (Mott et al 2000, PNAS, Yalcin et al 2005 Genetics, Durrant et al 2010 Genetics).
Research Interests
Papers共 246 篇Author StatisticsCo-AuthorSimilar Experts
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Mammalian Genomeno. 1 (2024): 31-55
Hanifa J. Abu-Toamih-Atami,Iqbal M. Lone,Ilona Binenbaum,Kareem Midlej,Eleftherios Pilalis,Richard Mott,Aristotelis Chatziioannou,Fuad A. Iraqi
crossref(2024)
Lukas Baumgarten,Bjorn Pieper,Baoxing Song,Sébastien Mane,Janne Lempe,Jonathan Lamb, Elizabeth L Cooke,Rachita Srivastava,Stefan Strütt,Danijela Žanko, Pedro Gp Casimiro,Asis Hallab,
PLoS biologyno. 7 (2023): e3002191-e3002191
Journal of Clinical Medicineno. 3212 (2023): 3212-3212
GENETICSno. 3 (2023)
Leilei Cui,Bin Yang,Shijun Xiao,Jun Gao,Amelie Baud,Delyth Graham,Martin McBride,Anna Dominiczak,Sebastian Schafer, Regina Lopez Aumatell,Carme Mont, Albert Fernandez Teruel,
Genome Biologyno. 1 (2023): 215-215
Research Square (Research Square) (2023)
PLANT GENOMEno. 1 (2023): n/a-n/a
in silico plantsno. 1 (2022)
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