基本信息
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职业迁徙
个人简介
Research interests
Research focused on drug discovery in motor neurone disease/amyotrophic lateral sclerosis (MND/ALS), and Parkinson’s disease from target identification to in vivo disease model testing and development of translational biomarkers for early clinical studies. Specific areas include:
Pharmacological manipulation of in vitro and in vivo model systems to dissect mechanisms in MND and find new targets
Small molecule drug development for inflammatory and oxidative stress targets including NRF2 pathway activators
Improving screening methodologies, evolving new in vivo screening paradigms with improved welfare, reduced biological variation and faster throughput
Identification of ‘translational’ biomarkers, applicable in both preclinical and clinical settings
Investigating novel cell therapy paradigms in MND/ALS
A large proportion of the work in my group is conducted in collaboration with Pharma and Biotech.
I am also co-founder and CSO of Keapstone Therapeutics, a spin-out from the University of Sheffield investigating KEAP1 inhibitors for disease modification in ALS and PD.
研究兴趣
论文共 53 篇作者统计合作学者相似作者
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crossref(2024)
ANALYSTno. 9 (2024): 2738-2746
Scott P Allen, Afnan Al Sultan, Elaine Kabucho Kibirige, Erin Tonkiss, Keaton J Hamer,Lydia M Castelli,Ya-Hui Lin,Sarah Roscoe, Nikolaos Stefanidis,Richard J Mead,J Robin Highley,Johnathan Cooper-Knock,
Frontiers in aging neuroscience (2023): 1151848-1151848
Peter J. Richardson,Daniel P. Smith,Alex de Giorgio, Xenia Snetkov, Joshua Almond-Thynne, Sara Cronin,Richard J. Mead,Christopher J. McDermott,Pamela J. Shaw
Translational Neurodegenerationno. 1 (2023): 47-47
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作者统计
#Papers: 54
#Citation: 2353
H-Index: 19
G-Index: 48
Sociability: 6
Diversity: 0
Activity: 1
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