基本信息
浏览量:73
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Research
The major focus of Dr. Deckelbaum’s laboratory is to determine regulatory mechanisms for cell-lipid particle interaction, and cell cholesterol and triglyceride metabolism. Current projects are defining the effects of lipid particle properties on their metabolism in the whole animal, and in cells, via receptor-mediated and receptor-independent pathways. Integrated with these studies are studies on how different lipids, omega-3 and other free fatty acids regulate gene expression and focus on genes and mechanisms affecting atherogenesis, myocardial infarction and stroke. Dr. Deckebaum’s initial research training as a postdoctoral fellow in biophysics using NMR, calorimetry, and X-ray techniques to study the structure of lipoproteins has allowed him throughout his career to understand the importance of physical structure of different lipids in the biochemistry and in the molecular biology of lipids and lipid metabolism. Having been funded continuously for over thirty years by NIH R01s and PPGs focusing on triglyceride emulsions, lipoprotein metabolism, and lipid metabolism in in vitro and in vivo, we have obtained very exciting results over the years showing that EPA/DHA rich diets have the ability to inhibit pathways associated with atherogenesis in four different rodent models. Our laboratory has shown that acute administration of omega-3 fatty acids also provides major neuro- and cardioprotection after stroke and myocardial infarction in rodent models. Of the pre- and postdoctoral trainees Dr. Deckelbaum has mentored over the past 30 years, over 45 now have full-time academic positions at universities or are heading nutrition-related roles in industry and government.
The major focus of Dr. Deckelbaum’s laboratory is to determine regulatory mechanisms for cell-lipid particle interaction, and cell cholesterol and triglyceride metabolism. Current projects are defining the effects of lipid particle properties on their metabolism in the whole animal, and in cells, via receptor-mediated and receptor-independent pathways. Integrated with these studies are studies on how different lipids, omega-3 and other free fatty acids regulate gene expression and focus on genes and mechanisms affecting atherogenesis, myocardial infarction and stroke. Dr. Deckebaum’s initial research training as a postdoctoral fellow in biophysics using NMR, calorimetry, and X-ray techniques to study the structure of lipoproteins has allowed him throughout his career to understand the importance of physical structure of different lipids in the biochemistry and in the molecular biology of lipids and lipid metabolism. Having been funded continuously for over thirty years by NIH R01s and PPGs focusing on triglyceride emulsions, lipoprotein metabolism, and lipid metabolism in in vitro and in vivo, we have obtained very exciting results over the years showing that EPA/DHA rich diets have the ability to inhibit pathways associated with atherogenesis in four different rodent models. Our laboratory has shown that acute administration of omega-3 fatty acids also provides major neuro- and cardioprotection after stroke and myocardial infarction in rodent models. Of the pre- and postdoctoral trainees Dr. Deckelbaum has mentored over the past 30 years, over 45 now have full-time academic positions at universities or are heading nutrition-related roles in industry and government.
研究兴趣
论文共 101 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Food and Nutrition Bulletinno. 2 (2016): 144-152
加载更多
作者统计
#Papers: 102
#Citation: 2113
H-Index: 24
G-Index: 45
Sociability: 6
Diversity: 3
Activity: 2
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn