基本信息
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Bio
Dr. Hawkes’s research concerns the structure and development of the mammalian cerebellum. His discovery of key patterning markers in the cerebellum – “zebrins” - is the foundation of the modern "zones-and-stripes" model of cerebellar organization. These studies of adult cerebellar architecture are the basis for understanding pattern formation during cerebellar development, which included the first identification of the canonical Reelin-Disabled signaling pathway. His collaborative studies of cerebellar development have extended to models of human disease including neuronal death in the childhood disorder Niemann-Pick, dysbindin-dystrobrevin interactions in nervous system correlates of muscular dystrophy, and the identification of a mutation in the ?1A-voltage-sensitive calcium channel gene that defined both novel in vivo roles for the gene in neuronal function and survival, and identified it as a key mammalian epilepsy locus. Finally, he invented and patented the dot immunobinding assay, an immunological technique that is used in labs worldwide and has become a “citation classic”.
Research Interests
Papers共 234 篇Author StatisticsCo-AuthorSimilar Experts
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Essentials of Cerebellum and Cerebellar Disorderspp.93-98, (2023)
Neural Circuit and Cognitive Development (2020)
The Cerebellumno. 5 (2018): 683-684
Cerebellum (London, England)no. 5 (2018): 654-682
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Author Statistics
#Papers: 236
#Citation: 17065
H-Index: 66
G-Index: 126
Sociability: 6
Diversity: 3
Activity: 2
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