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The objective of our work is to understand early vertebrate development at the molecular level. We study this problem in both the amphibian Xenopus, and in the mouse. Xenopus embryos are large and easily manipulated, so that the function of various macromolecules, such as RNA and protein, can be assayed by microinjection into living embryos. Functional assays in Xenopus can then be complemented by genetic knockouts in the mouse, to gain fuller understanding of the normal requirements for gene action in the developing embryo.
The objective of our work is to understand early vertebrate development at the molecular level. We study this problem in both the amphibian Xenopus, and in the mouse. Xenopus embryos are large and easily manipulated, so that the function of various macromolecules, such as RNA and protein, can be assayed by microinjection into living embryos. Functional assays in Xenopus can then be complemented by genetic knockouts in the mouse, to gain fuller understanding of the normal requirements for gene action in the developing embryo.
Research Interests
Papers共 314 篇Author StatisticsCo-AuthorSimilar Experts
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Cells & Developmentpp.203910-203910, (2024)
Aleksandr Kotov,Subham Seal,Mansour Alkobtawi, Vincent Kappes,Sofia Medina Ruiz, Hugo Arbes,Richard M. Harland,Leonid Peshkin,Anne H. Monsoro-Burq
DEVELOPMENTno. 3 (2024)
Michael J. Abrams, Lilian Zhang, Konnor von Emster,Brandon H Lee, Hannah Zeigler, Tanya Jain, Ali Jafri, Ying Feng,Richard M. Harland
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Michael J. Abrams, Lilian Zhang, Konnor von Emster,Brandon H. Lee, Hannah Zeigler, Tanya Jain, Ali Jafri, Zhiqin Chen,Richard M. Harland
biorxiv(2023)
Developmental biology (2023): A18-A20
Cold Spring Harbor Protocolsno. 1 (2022)
CSH Protocolsno. 5 (2022): pdb.top106195-pdb.top106195
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