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个人简介
Dr. Frothingham is the principal investigator of a research laboratory which studies Mycobacterium tuberculosis, the cause of tuberculosis, and Mycobacterium avium, a closely related bacterium causing serious infections in AIDS patients. We are pursuing two current projects.
The first project aims to develop vaccines against M. avium and M. tuberculosis. We inject mice with candidate plasmid DNA vaccines which produce bacterial proteins in mouse muscle. We use a variety of DNA adjuvants to modify the immune response. We hope to use DNA vaccination to protect against new infections and to modify the course of existing infections. We also hope to identify correlates of vaccine-induced protective immunity.
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Bryan E Hart, Rose Asrican,So-Yon Lim,Jaimie D Sixsmith,Regy Lukose,Sommer J R Souther,Swati D G Rayasam,Joseph W Saelens,Ching-Ju Chen,Sarah A Seay,Linda Berney-Meyer, Leslie Magtanong,
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