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The cAMP-regulated enhancer (CRE), initially identified in the Goodman lab, is a critical control element in many neuronal genes and the widespread presence of this element provides a mechanism that may allow coordinate regulation. Transcriptional signals mediated by the CRE depend upon the transcription factor CREB, which is activated through a variety of signaling pathways including cAMP, calcium, and growth factors. Phosphorylation of CREB leads to the recruitment of the CREB binding protein, CBP, which was also identified in the Goodman lab. CBP was the first example in metazoans of a transcriptional coactivator and has been shown to participate in virtually all positively regulated transcriptional pathways. Not surprisingly, perturbation of CBP function has profound effects on cell growth, differentiation, and development. One project in the lab uses laser microdissection and single cell RNASeq to identify genes in hippocampal granule cells that are induced by voluntary exercise. This study has identified a family of RNA transcripts that direct early steps in the formation of dendritic spines and current efforts (in collaboration with Gary Westbrook) are directed toward determining the contributions of the corresponding gene products to synaptic plasticity. A second project (in collaboration with Lulu Cambronne and Michael Cohen) is to elucidate the role of the nicotinamide adenine dinucleotide NAD+ in regulating cellular functions in health and disease. The ability of the biosensor developed in the lab to monitor free NAD+ levels in discrete subcellular compartments, which has never before been possible, will be important in sorting out the contribution of this molecule to neurodegeneration and the pathways connecting diet, gene regulation, and longevity.
The cAMP-regulated enhancer (CRE), initially identified in the Goodman lab, is a critical control element in many neuronal genes and the widespread presence of this element provides a mechanism that may allow coordinate regulation. Transcriptional signals mediated by the CRE depend upon the transcription factor CREB, which is activated through a variety of signaling pathways including cAMP, calcium, and growth factors. Phosphorylation of CREB leads to the recruitment of the CREB binding protein, CBP, which was also identified in the Goodman lab. CBP was the first example in metazoans of a transcriptional coactivator and has been shown to participate in virtually all positively regulated transcriptional pathways. Not surprisingly, perturbation of CBP function has profound effects on cell growth, differentiation, and development. One project in the lab uses laser microdissection and single cell RNASeq to identify genes in hippocampal granule cells that are induced by voluntary exercise. This study has identified a family of RNA transcripts that direct early steps in the formation of dendritic spines and current efforts (in collaboration with Gary Westbrook) are directed toward determining the contributions of the corresponding gene products to synaptic plasticity. A second project (in collaboration with Lulu Cambronne and Michael Cohen) is to elucidate the role of the nicotinamide adenine dinucleotide NAD+ in regulating cellular functions in health and disease. The ability of the biosensor developed in the lab to monitor free NAD+ levels in discrete subcellular compartments, which has never before been possible, will be important in sorting out the contribution of this molecule to neurodegeneration and the pathways connecting diet, gene regulation, and longevity.
Research Interests
Papers共 199 篇Author StatisticsCo-AuthorSimilar Experts
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Kevin Scaife, Steve L. Taylor, Lucie Parenicova,Richard E. Goodman, Trung D. Vo, Elisa Leune, Mohamed Abdelmoteleb, Yvonne Dommels
Yanisa Anaya, Raysa Rosario Martinez,Richard E. Goodman,Philip Johnson, Shashwat Vajpeyi,Xiaoning Lu,Ross Peterson, Sarah M. Weyers, Bella Breen, Kahler Newsham,Brian Scottoline,Anthony Clark,
Frontiers in Immunology (2024)
International Journal of Biometeorologypp.1-14, (2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
FRONTIERS IN ALLERGY (2022): 900573
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